Seroatlas · Human Serome Atlas

TNFRSF18

Tumor necrosis factor receptor superfamily member 18

Also known as: AITR, CD357, GITR, TNR18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5U5
Gene
TNFRSF18
Ensembl
ENSG00000186891
Chromosome
1
Canonical length
241 aa
Protein class
CD markers, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q9Y5U5|TNFRSF18
     1  MAQHGAMGAF RALCGLALLC ALSLGQRPTG GPGCGPGRLL LGTGTDARCC RVHTTRCCRD
    61  YPGEECCSEW DCMCVQPEFH CGDPCCTTCR HHPCPPGQGV QSQGKFSFGF QCIDCASGTF
   121  SGGHEGHCKP WTDCTQFGFL TVFPGNKTHN AVCVPGSPPA EPLGWLTVVL LAVAACVLLL
   181  TSAQLGLHIW QLRSQCMWPR ETQLLLEVPP STEDARSCQF PEEERGERSA EEKGRLGDLW
   241  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • skin: 37 nTPM
  • cervix: 9.8 nTPM
  • spleen: 9.2 nTPM
  • parathyroid gland: 8.9 nTPM
  • small intestine: 7.1 nTPM
  • appendix: 6.9 nTPM

Single-cell type

  • innate lymphoid cells: 224 nCPM
  • plasma cells: 145 nCPM
  • basal keratinocytes: 123 nCPM
  • nk-cells: 118 nCPM
  • endometrial secretory cells: 97 nCPM
  • thymocytes: 94 nCPM

Immune cell

  • NK-cell: 185 nTPM
  • T-reg: 72 nTPM
  • memory CD4 T-cell: 29 nTPM
  • MAIT T-cell: 13 nTPM
  • naive B-cell: 12 nTPM
  • gdT-cell: 6.9 nTPM

Brain region

  • cerebellum: 4.6 nTPM
  • cerebral cortex: 4.6 nTPM
  • pons: 2.1 nTPM
  • white matter: 1.8 nTPM
  • medulla oblongata: 1.6 nTPM
  • amygdala: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0
gnomAD missense Z
-0.57
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFRSF18 as an antibody target. Whether an autoantibody or antibody against TNFRSF18 could matter depends on whether native TNFRSF18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFRSF18 is annotated at the cell surface, where native TNFRSF18 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TNFRSF18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNFRSF18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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