TNFRSF1B

Protein identityUniProt · HPA

UniProt accession

P20333

Gene

TNFRSF1B

Ensembl

ENSG00000028137

Chromosome

1

Canonical length

461 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>P20333|TNFRSF1B
     1  MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG
    61  QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC
   121  RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR
   181  PHQICNVVAI PGNASMDAVC TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS
   241  FLLPMGPSPP AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV
   301  PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA PGVEASGAGE
   361  ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ ASSTMGDTDS SPSESPKDEQ
   421  VPFSKEECAF RSQLETPETL LGSTEEKPLP LGVPDAGMKP S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

65 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for TNFRSF1B from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.48

gnomAD pLI

0.5

gnomAD missense Z

0.93

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• aortic valve development
• cellular response to lipopolysaccharide
• extrinsic apoptotic signaling pathway
• inflammatory response
• intrinsic apoptotic signaling pathway in response to DNA damage
• negative regulation of cardiac muscle hypertrophy
• negative regulation of extracellular matrix constituent secretion
• negative regulation of neuroinflammatory response
• positive regulation of apoptotic process involved in morphogenesis
• positive regulation of membrane protein ectodomain proteolysis
• positive regulation of myelination
• positive regulation of oligodendrocyte differentiation
• pulmonary valve development
• regulation of cytokine production involved in immune response
• regulation of myelination
• regulation of neuroinflammatory response
• regulation of T cell cytokine production
• regulation of T cell proliferation
• RNA destabilization
• tumor necrosis factor-mediated signaling pathway
• glial cell-neuron signaling

Molecular functions

• tumor necrosis factor binding
• tumor necrosis factor receptor activity
• ubiquitin protein ligase binding

Cellular components

• extracellular region
• membrane
• membrane raft
• plasma membrane
• specific granule membrane
• tumor necrosis factor receptor superfamily complex

Protein domainsUniProt · Pfam · InterPro

• TNFR/NGFR cysteine-rich region
• TNFR/NGFR cysteine-rich region
• Tumour necrosis factor receptor 1B
• Tumor necrosis factor receptor 1B, N-terminal
• TNF and chemokine receptor-like

KeywordsUniProt

• Apoptosis
• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Pharmaceutical
• Phosphoprotein
• Receptor
• Repeat
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TNFRSF1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BMX
• ASB3
• TNF
• TRAF1
• TRAF2