Seroatlas · Human Serome Atlas

TNFRSF11B

Tumor necrosis factor receptor superfamily member 11B

Also known as: OCIF, OPG, TR1, TR11B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00300
Gene
TNFRSF11B
Ensembl
ENSG00000164761
Chromosome
8
Canonical length
401 aa
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Nucleoli,Golgi apparatus
Secretome location
Secreted in other tissues
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>O00300|TNFRSF11B
     1  MNNLLCCALV FLDISIKWTT QETFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT
    61  VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK
   121  HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT
   181  HDNICSGNSE STQKCGIDVT LCEEAFFRFA VPTKFTPNWL SVLVDNLPGT KVNAESVERI
   241  KRQHSSQEQT FQLLKLWKHQ NKDQDIVKKI IQDIDLCENS VQRHIGHANL TFEQLRSLME
   301  SLPGKKVGAE DIEKTIKACK PSDQILKLLS LWRIKNGDQD TLKGLMHALK HSKTYHFPKT
   361  VTQSLKKTIR FLHSFTMYKL YQKLFLEMIG NQVQSVKISC L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
192 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 192 nTPM
  • thyroid gland: 95 nTPM
  • kidney: 28 nTPM
  • liver: 13 nTPM
  • lung: 11 nTPM
  • urinary bladder: 10 nTPM

Single-cell type

  • breast lactating cells: 1,609 nCPM
  • renal collecting duct principal cells: 87 nCPM
  • loop of henle epithelial cells: 73 nCPM
  • epicardial cells: 68 nCPM
  • breast secretory cells: 65 nCPM
  • mesothelial cells: 48 nCPM

Immune cell

  • plasmacytoid DC: 4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • medulla oblongata: 5.9 nTPM
  • white matter: 3.7 nTPM
  • choroid plexus: 3.2 nTPM
  • spinal cord: 2.7 nTPM
  • cerebral cortex: 2.6 nTPM
  • basal ganglia: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNFRSF11B.

Disease | AllUniProt

Conditions TNFRSF11B is implicated in, by any mechanism.

  • Paget disease of bone 5, juvenile-onset (PDB5) MIM:239000

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 247 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hyperphosphatasemia with bone disease

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.16
gnomAD missense Z
0.84
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNFRSF11B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFRSF11B as an antibody target. Whether an autoantibody or antibody against TNFRSF11B could matter depends on whether native TNFRSF11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFRSF11B is annotated as secreted, so native TNFRSF11B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TNFRSF11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNFRSF11B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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