Seroatlas · Human Serome Atlas

TMEM207

Transmembrane protein 207

Also known as: TM207_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWW9
Gene: TMEM207
Ensembl: ENSG00000198398
Chromosome: 3
Canonical length: 146 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>Q6UWW9|TMEM207
     1  MSRSRLFSVT SAISTIGILC LPLFQLVLSD LPCEEDEMCV NYNDQHPNGW YIWILLLLVL
    61  VAALLCGAVV LCLQCWLRRP RIDSHRRTMA VFAVGDLDSI YGTEAAVSPT VGIHLQTQTP
   121  DLYPVPAPCF GPLGSPPPYE EIVKTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM207 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

kidney: 17 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

loop of henle epithelial cells: 33 nCPM
early primary spermatocytes: 2.3 nCPM
distal convoluted tubule cells: 1.7 nCPM
proximal tubule cells: 1.3 nCPM
renal collecting duct intercalated cells: 1.2 nCPM
cardiomyocytes: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

early endosome membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 207

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM207 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

WWOX

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM207 as an antibody target. Whether an autoantibody or antibody against TMEM207 could matter depends on whether native TMEM207 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM207 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM207 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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