Seroatlas · Human Serome Atlas

VOPP1

WW domain binding protein VOPP1

Also known as: DKFZp564K0822, ECop, FLJ20532, GASP, VOPP1_HUMAN, WBP1L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AW1
Gene: VOPP1
Ensembl: ENSG00000154978
Chromosome: 7
Canonical length: 172 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables enzyme binding activity. Located in cytoplasmic vesicle membrane; late endosome; and lysosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q96AW1|VOPP1
     1  MRRQPAKVAA LLLGLLLECT EAKKHCWYFE GLYPTYYICR SYEDCCGSRC CVRALSIQRL
    61  WYFWFLLMMG VLFCCGAGFF IRRRMYPPPL IEEPAFNVSY TRQPPNPGPG AQQPGPPYYT
   121  DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA CPPPPAYCNT PPPPYEQVVK AK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VOPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 233 nTPM

Expression across tissuesHPA

Tissue

retina: 233 nTPM
thymus: 107 nTPM
lymph node: 93 nTPM
tonsil: 74 nTPM
spleen: 73 nTPM
appendix: 63 nTPM

Single-cell type

cone photoreceptor cells: 1,263 nCPM
rod photoreceptor cells: 841 nCPM
plasma cells: 729 nCPM
cdc: 410 nCPM
neutrophils: 398 nCPM
thyrotrophs: 389 nCPM

Immune cell

memory B-cell: 75 nTPM
T-reg: 42 nTPM
naive B-cell: 39 nTPM
eosinophil: 36 nTPM
memory CD8 T-cell: 33 nTPM
memory CD4 T-cell: 32 nTPM

Brain region

thalamus: 122 nTPM
midbrain: 114 nTPM
amygdala: 98 nTPM
hypothalamus: 97 nTPM
white matter: 97 nTPM
spinal cord: 96 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.33
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

enzyme binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Vesicular, overexpressed in cancer, prosurvival protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VOPP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

WWOX

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VOPP1 as an antibody target. Whether an autoantibody or antibody against VOPP1 could matter depends on whether native VOPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VOPP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VOPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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