TFAP2C
Transcription factor AP-2 gamma
Also known as: AP2-GAMMA, AP2C_HUMAN, ERF1, hAP-2g, TFAP2G
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q92754
- Gene
- TFAP2C
- Ensembl
- ENSG00000087510
- Chromosome
- 20
- Canonical length
- 450 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
450 residues, UniProt reviewed canonical sequence.
>Q92754|TFAP2C
1 MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG VAEYQPPPYF
61 PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ QAWPGRQSQE GAGLPSHHGR
121 PAGLLPHLSG LEAGAVSARR DAYRRSDLLL PHAHALDAAG LAENLGLHDM PHQMDEVQNV
181 DDQHLLLHDQ TVIRKGPISM TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY
241 KVTVAEVQRR LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT
301 LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN MLLAAQQLCK
361 EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF GSQAICAAVS ALQNYIKEAL
421 IVIDKSYMNP GDQSPADSNK TLEKMEKHRKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TFAP2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- skin: 50 nTPM
- esophagus: 28 nTPM
- breast: 24 nTPM
- cervix: 21 nTPM
- salivary gland: 20 nTPM
- vagina: 19 nTPM
Single-cell type
- breast myoepithelial cells: 149 nCPM
- syncytiotrophoblasts: 129 nCPM
- basal keratinocytes: 128 nCPM
- migrating cytotrophoblasts: 125 nCPM
- suprabasal keratinocytes: 117 nCPM
- cytotrophoblasts: 116 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hippocampal formation: 3 nTPM
- cerebral cortex: 2.4 nTPM
- amygdala: 2.3 nTPM
- pons: 2.2 nTPM
- white matter: 1.6 nTPM
- medulla oblongata: 1.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.37
- gnomAD pLI
- 0.92
- gnomAD missense Z
- 2.46
- DepMap mean gene effect
- -0.21
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell-cell signaling
- cerebral cortex development
- dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
- epithelial cell proliferation involved in mammary gland duct elongation
- forebrain neuron fate commitment
- germ-line stem cell population maintenance
- hair follicle development
- inner cell mass cell differentiation
- keratinocyte development
- male gonad development
- morula formation
- negative regulation of gene expression, epigenetic
- positive regulation of transcription by RNA polymerase II
- regulation of cell population proliferation
- regulation of epidermis development
- regulation of transcription by RNA polymerase II
- sebaceous gland development
- somatic stem cell population maintenance
- stem cell differentiation
- transcription by RNA polymerase II
- trophectodermal cell differentiation
Molecular functions
- DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Transcription factor AP-2
- Transcription factor AP-2, C-terminal
- Transcription factor AP-2
- Transcription factor AP-2 gamma
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TFAP2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TFAP2C as an antibody target. Whether an autoantibody or antibody against TFAP2C could matter depends on whether native TFAP2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TFAP2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TFAP2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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