Seroatlas · Human Serome Atlas

PIAS4

E3 SUMO-protein ligase PIAS4

Also known as: FLJ12419, PIAS4_HUMAN, Piasg, PIASY, ZMIZ6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N2W9
Gene
PIAS4
Ensembl
ENSG00000105229
Chromosome
19
Canonical length
510 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome

OverviewNCBI Gene

Enables SUMO ligase activity and ubiquitin protein ligase binding activity. Involved in negative regulation of protein localization to chromatin; protein sumoylation; and regulation of primary metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>Q8N2W9|PIAS4
     1  MAAELVEAKN MVMSFRVSDL QMLLGFVGRS KSGLKHELVT RALQLVQFDC SPELFKKIKE
    61  LYETRYAKKN SEPAPQPHRP LDPLTMHSTY DRAGAVPRTP LAGPNIDYPV LYGKYLNGLG
   121  RLPAKTLKPE VRLVKLPFFN MLDELLKPTE LVPQNNEKLQ ESPCIFALTP RQVELIRNSR
   181  ELQPGVKAVQ VVLRICYSDT SCPQEDQYPP NIAVKVNHSY CSVPGYYPSN KPGVEPKRPC
   241  RPINLTHLMY LSSATNRITV TWGNYGKSYS VALYLVRQLT SSELLQRLKT IGVKHPELCK
   301  ALVKEKLRLD PDSEIATTGV RVSLICPLVK MRLSVPCRAE TCAHLQCFDA VFYLQMNEKK
   361  PTWMCPVCDK PAPYDQLIID GLLSKILSEC EDADEIEYLV DGSWCPIRAE KERSCSPQGA
   421  ILVLGPSDAN GLLPAPSVNG SGALGSTGGG GPVGSMENGK PGADVVDLTL DSSSSSEDEE
   481  EEEEEEEDED EEGPRPKRRC PFQKGLVPAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIAS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • testis: 37 nTPM
  • cerebellum: 25 nTPM
  • liver: 15 nTPM
  • colon: 15 nTPM
  • spinal cord: 15 nTPM
  • pancreas: 14 nTPM

Single-cell type

  • late spermatids: 409 nCPM
  • late primary spermatocytes: 147 nCPM
  • early spermatids: 86 nCPM
  • oocytes: 74 nCPM
  • undifferentiated spermatogonia: 49 nCPM
  • syncytiotrophoblasts: 49 nCPM

Immune cell

  • eosinophil: 20 nTPM
  • non-classical monocyte: 20 nTPM
  • NK-cell: 17 nTPM
  • memory B-cell: 16 nTPM
  • neutrophil: 16 nTPM
  • gdT-cell: 15 nTPM

Brain region

  • white matter: 38 nTPM
  • medulla oblongata: 29 nTPM
  • basal ganglia: 27 nTPM
  • midbrain: 27 nTPM
  • cerebellum: 27 nTPM
  • cerebral cortex: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.12
gnomAD pLI
1
gnomAD missense Z
2.63
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIAS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIAS4 as an antibody target. Whether an autoantibody or antibody against PIAS4 could matter depends on whether native PIAS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIAS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIAS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PIAS4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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