APOBEC1

Protein identityUniProt · HPA

UniProt accession

P41238

Gene

APOBEC1

Ensembl

ENSG00000111701

Chromosome

12

Canonical length

236 aa

Protein class

Enzymes, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>P41238|APOBEC1
     1  MTSEKGPSTG DPTLRRRIEP WEFDVFYDPR ELRKEACLLY EIKWGMSRKI WRSSGKNTTN
    61  HVEVNFIKKF TSERDFHPSM SCSITWFLSW SPCWECSQAI REFLSRHPGV TLVIYVARLF
   121  WHMDQQNRQG LRDLVNSGVT IQIMRASEYY HCWRNFVNYP PGDEAHWPQY PPLWMMLYAL
   181  ELHCIILSLP PCLKISRRWQ NHLTFFRLHL QNCHYQTIPP HILLATGLIH PSVAWR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOBEC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

27 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.59

gnomAD pLI

0

gnomAD missense Z

0.77

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromosomal 5-methylcytosine DNA demethylation pathway
• cytidine to uridine editing
• establishment of localization in cell
• lipid metabolic process
• lipoprotein biosynthetic process
• lipoprotein transport
• mRNA modification
• mRNA processing
• mRNA stabilization
• negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
• negative regulation of triglyceride metabolic process
• positive regulation of gene expression via chromosomal CpG island demethylation
• regulation of cell population proliferation
• response to gamma radiation
• triglyceride metabolic process

Molecular functions

• cytidine deaminase activity
• mRNA 3'-UTR AU-rich region binding
• RNA binding
• zinc ion binding

Cellular components

• apolipoprotein B mRNA editing enzyme complex
• cytoplasm
• mRNA editing complex
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Cytidine and deoxycytidylate deaminase domain
• APOBEC/CMP deaminase, zinc-binding
• Cytidine deaminase-like
• APOBEC Cytidine Deaminase
• C->U-editing enzyme APOBEC-1
• APOBEC4-like -AID/APOBEC-deaminase

KeywordsUniProt

• Cytoplasm
• Hydrolase
• Metal-binding
• mRNA processing
• Nucleus
• Zinc

InteractionsUniProt · HPA

Protein binding partners of APOBEC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• A1CF
• HNRPAB
• RBM47
• SYNCRIP
• HNRNPAB