Seroatlas · Human Serome Atlas

ODAD3

Outer dynein arm-docking complex subunit 3

Also known as: CCDC151, MGC20983, ODA10, ODAD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5D8V7
Gene: ODAD3
Ensembl: ENSG00000198003
Chromosome: 19
Canonical length: 595 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Principal piece

OverviewNCBI Gene

This gene encodes a protein containing coiled-coil domains. The encoded protein functions in outer dynein arm assembly and is required for motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>A5D8V7|ODAD3
     1  MTSPLCRAAS ANALPPQDQA STPSSRVKGR EASGKPSHLR GKGTAQAWTP GRSKGGSFHR
    61  GAGKPSVHSQ VAELHKKIQL LEGDRKAFFE SSQWNIKKNQ ETISQLRKET KALELKLLDL
   121  LKGDEKVVQA VIREWKWEKP YLKNRTGQAL EHLDHRLREK VKQQNALRHQ VVLRQRRLEE
   181  LQLQHSLRLL EMAEAQNRHT EVAKTMRNLE NRLEKAQMKA QEAEHITSVY LQLKAYLMDE
   241  SLNLENRLDS MEAEVVRTKH ELEALHVVNQ EALNARDIAK NQLQYLEETL VRERKKRERY
   301  ISECKKRAEE KKLENERMER KTHREHLLLQ SDDTIQDSLH AKEEELRQRW SMYQMEVIFG
   361  KVKDATGTDE THSLVRRFLA QGDTFAQLET LKSENEQTLV RLKQEKQQLQ RELEDLKYSG
   421  EATLVSQQKL QAEAQERLKK EERRHAEAKD QLERALRAMQ VAKDSLEHLA SKLIHITVED
   481  GRFAGKELDP QADNYVPNLL GLVEEKLLKL QAQLQGHDVQ EMLCHIANRE FLASLEGRLP
   541  EYNTRIALPL ATSKDKFFDE ESEEEDNEVV TRASLKIRSQ KLIESHKKHR RSRRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ODAD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 14 nTPM
testis: 10 nTPM
parathyroid gland: 9.2 nTPM
fallopian tube: 8 nTPM
pituitary gland: 6.7 nTPM
hippocampal formation: 4.8 nTPM

Single-cell type

kupffer cells: 110 nCPM
respiratory ciliated cells: 91 nCPM
ependymal cells: 56 nCPM
choroid plexus epithelial cells: 55 nCPM
fallopian tube ciliated cells: 54 nCPM
decidual stromal cells: 48 nCPM

Immune cell

intermediate monocyte: 0.5 nTPM
memory B-cell: 0.4 nTPM
classical monocyte: 0.1 nTPM
myeloid DC: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 24 nTPM
midbrain: 7.1 nTPM
medulla oblongata: 6.2 nTPM
spinal cord: 3.4 nTPM
hippocampal formation: 2.8 nTPM
pons: 2.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ODAD3.

Disease | AllUniProt

Conditions ODAD3 is implicated in, by any mechanism.

Ciliary dyskinesia, primary, 30 (CILD30) MIM:616037

Disease | GeneticClinVar

37 pathogenic / likely-pathogenic of 437 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Primary ciliary dyskinesia 30
Kartagener syndrome
Inborn genetic diseases
Primary ciliary dyskinesia
ODAD3-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Outer dynein arm-docking complex subunit 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ODAD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ODAD3 as an antibody target. Whether an autoantibody or antibody against ODAD3 could matter depends on whether native ODAD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ODAD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ODAD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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