Seroatlas · Human Serome Atlas

ZNF512

Zinc finger protein 512

Also known as: KIAA1805, ZN512_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96ME7
Gene
ZNF512
Ensembl
ENSG00000243943
Chromosome
2
Canonical length
567 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein containing four putative zinc finger motifs. Zinc finger motifs may bind to proteins or nucleic acids. Zinc finger-containing proteins are involved in a variety of processes, including regulation of transcription. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

567 residues, UniProt reviewed canonical sequence.

>Q96ME7|ZNF512
     1  MSSRLGAVPA TSGPTTFKQQ RSTRIVGAKN SRTQCSIKDN SFQYTIPHDD SLSGSSSASS
    61  CEPVSDFPAS FRKSTYWMKM RRIKPAATSH VEGSGGVSAK GKRKPRQEED EDYREFPQKK
   121  HKLYGRKQRP KTQPNPKSQA RRIRKEPPVY AAGSLEEQWY LEIVDKGSVS CPTCQAVGRK
   181  TIEGLKKHME NCKQEMFTCH HCGKQLRSLA GMKYHVMANH NSLPILKAGD EIDEPSERER
   241  LRTVLKRLGK LRCMRESCSS SFTSIMGYLY HVRKCGKGAA ELEKMTLKCH HCGKPYRSKA
   301  GLAYHLRSEH GPISFFPESG QPECLKEMNL ESKSGGRVQR RSAKIAVYHL QELASAELAK
   361  EWPKRKVLQD LVPDDRKLKY TRPGLPTFSQ EVLHKWKTDI KKYHRIQCPN QGCEAVYSSV
   421  SGLKAHLGSC TLGNFVAGKY KCLLCQKEFV SESGVKYHIN SVHAEDWFVV NPTTTKSFEK
   481  LMKIKQRQQE EEKRRQQHRS RRSLRRRQQP GIELPETELS LRVGKDQRRN NEELVVSASC
   541  KEPEQEPVPA QFQKVKPPKT NHKRGRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF512 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 30 nTPM
  • thymus: 25 nTPM
  • retina: 24 nTPM
  • endometrium: 23 nTPM
  • blood vessel: 21 nTPM
  • cervix: 21 nTPM

Single-cell type

  • podocytes: 51 nCPM
  • renal collecting duct intercalated cells: 49 nCPM
  • papillary tip epithelial cells: 45 nCPM
  • renal collecting duct principal cells: 44 nCPM
  • renal connecting tubule cells: 43 nCPM
  • loop of henle epithelial cells: 43 nCPM

Immune cell

  • basophil: 25 nTPM
  • NK-cell: 22 nTPM
  • naive CD4 T-cell: 17 nTPM
  • memory CD8 T-cell: 15 nTPM
  • naive CD8 T-cell: 15 nTPM
  • MAIT T-cell: 14 nTPM

Brain region

  • hypothalamus: 28 nTPM
  • cerebral cortex: 27 nTPM
  • white matter: 24 nTPM
  • midbrain: 24 nTPM
  • thalamus: 21 nTPM
  • pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
gnomAD missense Z
2.41
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF512 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF512 as an antibody target. Whether an autoantibody or antibody against ZNF512 could matter depends on whether native ZNF512 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF512 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF512 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF512. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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