Seroatlas · Human Serome Atlas

BCL11B

B-cell lymphoma/leukemia 11B

Also known as: BC11B_HUMAN, CTIP-2, CTIP2, hRIT1-alpha, SMARCM2, ZNF856B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C0K0
Gene
BCL11B
Ensembl
ENSG00000127152
Chromosome
14
Canonical length
894 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

894 residues, UniProt reviewed canonical sequence.

>Q9C0K0|BCL11B
     1  MSRRKQGNPQ HLSQRELITP EADHVEAAIL EEDEGLEIEE PSGLGLMVGG PDPDLLTCGQ
    61  CQMNFPLGDI LVFIEHKRKQ CGGSLGACYD KALDKDSPPP SSRSELRKVS EPVEIGIQVT
   121  PDEDDHLLSP TKGICPKQEN IAGPCRPAQL PAVAPIAASS HPHSSVITSP LRALGALPPC
   181  LPLPCCSARP VSGDGTQGEG QTEAPFGCQC QLSGKDEPSS YICTTCKQPF NSAWFLLQHA
   241  QNTHGFRIYL EPGPASSSLT PRLTIPPPLG PEAVAQSPLM NFLGDSNPFN LLRMTGPILR
   301  DHPGFGEGRL PGTPPLFSPP PRHHLDPHRL SAEEMGLVAQ HPSAFDRVMR LNPMAIDSPA
   361  MDFSRRLREL AGNSSTPPPV SPGRGNPMHR LLNPFQPSPK SPFLSTPPLP PMPPGGTPPP
   421  QPPAKSKSCE FCGKTFKFQS NLIVHRRSHT GEKPYKCQLC DHACSQASKL KRHMKTHMHK
   481  AGSLAGRSDD GLSAASSPEP GTSELAGEGL KAADGDFRHH ESDPSLGHEP EEEDEEEEEE
   541  EEELLLENES RPESSFSMDS ELSRNRENGG GGVPGVPGAG GGAAKALADE KALVLGKVME
   601  NVGLGALPQY GELLADKQKR GAFLKRAAGG GDAGDDDDAG GCGDAGAGGA VNGRGGGFAP
   661  GTEPFPGLFP RKPAPLPSPG LNSAAKRIKV EKDLELPPAA LIPSENVYSQ WLVGYAASRH
   721  FMKDPFLGFT DARQSPFATS SEHSSENGSL RFSTPPGDLL DGGLSGRSGT ASGGSTPHLG
   781  GPGPGRPSSK EGRRSDTCEY CGKVFKNCSN LTVHRRSHTG ERPYKCELCN YACAQSSKLT
   841  RHMKTHGQIG KEVYRCDICQ MPFSVYSTLE KHMKKWHGEH LLTNDVKIEQ AERS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 34 nTPM
  • skin: 14 nTPM
  • basal ganglia: 12 nTPM
  • lymph node: 9.5 nTPM
  • tonsil: 7 nTPM
  • appendix: 4.8 nTPM

Single-cell type

  • t-cells: 675 nCPM
  • thymocytes: 247 nCPM
  • brain inhibitory neurons: 201 nCPM
  • nk-cells: 151 nCPM
  • basal keratinocytes: 133 nCPM
  • suprabasal keratinocytes: 113 nCPM

Immune cell

  • naive CD4 T-cell: 4.6 nTPM
  • naive CD8 T-cell: 3.1 nTPM
  • memory CD4 T-cell: 2.8 nTPM
  • memory CD8 T-cell: 2.4 nTPM
  • T-reg: 2.1 nTPM
  • gdT-cell: 2 nTPM

Brain region

  • basal ganglia: 49 nTPM
  • hippocampal formation: 44 nTPM
  • cerebral cortex: 40 nTPM
  • amygdala: 22 nTPM
  • white matter: 13 nTPM
  • spinal cord: 7.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BCL11B.

Disease | AllUniProt

Conditions BCL11B is implicated in, by any mechanism.

  • Immunodeficiency 49, severe combined (IMD49) MIM:617237
  • Intellectual developmental disorder with speech delay, dysmorphic facies, and T-cell abnormalities (IDDSFTA) MIM:618092

Disease | GeneticClinVar

68 pathogenic / likely-pathogenic of 947 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual developmental disorder with speech delay, dysmorphic facies, and t-cell abnormalities
  • Inborn genetic diseases
  • BCL11B-related disorder
  • Immunodeficiency 49
  • See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
4.71
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL11B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL11B as an antibody target. Whether an autoantibody or antibody against BCL11B could matter depends on whether native BCL11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL11B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BCL11B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...