Seroatlas · Human Serome Atlas

FGFR1OP2

FGFR1 oncogene partner 2

Also known as: DKFZp564O1863, FGOP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVK5
Gene: FGFR1OP2
Ensembl: ENSG00000111790
Chromosome: 12
Canonical length: 253 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in response to wounding. Predicted to act upstream of or within wound healing. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q9NVK5|FGFR1OP2
     1  MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALNKRV EAMKQYQEEI QELNEVARHR
    61  PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI MSKYREQMFR LLMASKKDDP
   121  GIIMKLKEQH SKIDMVHRNK SEGFFLDASR HILEAPQHGL ERRHLEANQN ELQAHVDQIT
   181  EMAAVMRKAI EIDEQQGCKE QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS
   241  ALVTNSDLSL RKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGFR1OP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 58 nTPM
ovary: 48 nTPM
lymph node: 40 nTPM
adrenal gland: 39 nTPM
cerebral cortex: 34 nTPM
thymus: 34 nTPM

Single-cell type

platelets: 259 nCPM
megakaryocytes: 216 nCPM
peritubular myoid cells: 213 nCPM
hematopoietic stem cells: 177 nCPM
plasma cells: 158 nCPM
neutrophils: 157 nCPM

Immune cell

basophil: 81 nTPM
T-reg: 61 nTPM
eosinophil: 41 nTPM
naive CD8 T-cell: 33 nTPM
memory CD4 T-cell: 33 nTPM
neutrophil: 32 nTPM

Brain region

white matter: 74 nTPM
cerebral cortex: 60 nTPM
basal ganglia: 51 nTPM
spinal cord: 46 nTPM
medulla oblongata: 45 nTPM
cerebellum: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGFR1OP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGFR1OP2 as an antibody target. Whether an autoantibody or antibody against FGFR1OP2 could matter depends on whether native FGFR1OP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGFR1OP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FGFR1OP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...