SIKE1
Suppressor of IKBKE 1
Also known as: FLJ21168, SIKE, SIKE1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BRV8
- Gene
- SIKE1
- Ensembl
- ENSG00000052723
- Chromosome
- 1
- Canonical length
- 207 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Focal adhesion sites
OverviewNCBI Gene
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
207 residues, UniProt reviewed canonical sequence.
>Q9BRV8|SIKE1
1 MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL PDQYQEDASD
61 MKDMSKYKPH ILLSQENTQI RDLQQENREL WISLEEHQDA LELIMSKYRK QMLQLMVAKK
121 AVDAEPVLKA HQSHSAEIES QIDRICEMGE VMRKAVQVDD DQFCKIQEKL AQLELENKEL
181 RELLSISSES LQARKENSMD TASQAIKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SIKE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- thymus: 13 nTPM
- skin: 13 nTPM
- liver: 11 nTPM
- lymph node: 11 nTPM
- tonsil: 11 nTPM
- kidney: 10 nTPM
Single-cell type
- esophageal apical cells: 116 nCPM
- oocytes: 83 nCPM
- late spermatids: 74 nCPM
- esophageal suprabasal cells: 62 nCPM
- parietal cells: 55 nCPM
- hepatocytes: 50 nCPM
Immune cell
- basophil: 6 nTPM
- MAIT T-cell: 2.8 nTPM
- naive CD8 T-cell: 2.8 nTPM
- plasmacytoid DC: 2.7 nTPM
- naive CD4 T-cell: 2.6 nTPM
- NK-cell: 2.5 nTPM
Brain region
- cerebellum: 18 nTPM
- thalamus: 18 nTPM
- hypothalamus: 17 nTPM
- medulla oblongata: 15 nTPM
- pons: 15 nTPM
- white matter: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.7
- gnomAD pLI
- 0.2
- gnomAD missense Z
- 0.44
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SIKE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SIKE1 as an antibody target. Whether an autoantibody or antibody against SIKE1 could matter depends on whether native SIKE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SIKE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SIKE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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