Seroatlas · Human Serome Atlas

STK11

Serine/threonine-protein kinase STK11

Also known as: LKB1, PJS, STK11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15831
Gene
STK11
Ensembl
ENSG00000118046
Chromosome
19
Canonical length
433 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium,Centrosome,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q15831|STK11
     1  MEVVDPQQLG MFTEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY
    61  GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHKNV IQLVDVLYNE
   121  EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFCQL IDGLEYLHSQ GIVHKDIKPG
   181  NLLLTTGGTL KISDLGVAEA LHPFAADDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS
   241  AGVTLYNITT GLYPFEGDNI YKLFENIGKG SYAIPGDCGP PLSDLLKGML EYEPAKRFSI
   301  RQIRQHSWFR KKHPPAEAPV PIPPSPDTKD RWRSMTVVPY LEDLHGADED EDLFDIEDDI
   361  IYTQDFTVPG QVPEEEASHN GQRRGLPKAV CMNGTEAAQL STKSRAEGRA PNPARKACSA
   421  SSKIRRLSAC KQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
106 nTPM

Expression across tissuesHPA

Tissue

  • testis: 106 nTPM
  • skeletal muscle: 89 nTPM
  • cerebellum: 46 nTPM
  • spleen: 41 nTPM
  • heart muscle: 39 nTPM
  • liver: 37 nTPM

Single-cell type

  • late spermatids: 622 nCPM
  • epicardial cells: 350 nCPM
  • late primary spermatocytes: 230 nCPM
  • early spermatids: 142 nCPM
  • erythrocyte progenitors: 54 nCPM
  • megakaryocytes: 50 nCPM

Immune cell

  • neutrophil: 9.9 nTPM
  • non-classical monocyte: 5.8 nTPM
  • intermediate monocyte: 5.5 nTPM
  • eosinophil: 3.9 nTPM
  • classical monocyte: 3.3 nTPM
  • memory B-cell: 2.3 nTPM

Brain region

  • choroid plexus: 60 nTPM
  • cerebellum: 59 nTPM
  • cerebral cortex: 53 nTPM
  • midbrain: 50 nTPM
  • medulla oblongata: 48 nTPM
  • amygdala: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STK11.

Disease | AllUniProt

Conditions STK11 is implicated in, by any mechanism.

Disease | GeneticClinVar

407 pathogenic / likely-pathogenic of 3,017 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
0.99
gnomAD missense Z
1.6
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STK11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK11 as an antibody target. Whether an autoantibody or antibody against STK11 could matter depends on whether native STK11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STK11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STK11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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