CAB39L
Calcium-binding protein 39-like
Also known as: bA103J18.3, CB39L_HUMAN, FLJ12577, MO2L
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H9S4
- Gene
- CAB39L
- Ensembl
- ENSG00000102547
- Chromosome
- 13
- Canonical length
- 337 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm. Predicted to be part of serine/threonine protein kinase complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
337 residues, UniProt reviewed canonical sequence.
>Q9H9S4|CAB39L
1 MKKMPLFSKS HKNPAEIVKI LKDNLAILEK QDKKTDKASE EVSKSLQAMK EILCGTNEKE
61 PPTEAVAQLA QELYSSGLLV TLIADLQLID FEGKKDVTQI FNNILRRQIG TRSPTVEYIS
121 AHPHILFMLL KGYEAPQIAL RCGIMLRECI RHEPLAKIIL FSNQFRDFFK YVELSTFDIA
181 SDAFATFKDL LTRHKVLVAD FLEQNYDTIF EDYEKLLQSE NYVTKRQSLK LLGELILDRH
241 NFAIMTKYIS KPENLKLMMN LLRDKSPNIQ FEAFHVFKVF VASPHKTQPI VEILLKNQPK
301 LIEFLSSFQK ERTDDEQFAD EKNYLIKQIR DLKKTAPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CAB39L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 88 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 88 nTPM
- colon: 53 nTPM
- prostate: 39 nTPM
- adrenal gland: 35 nTPM
- breast: 35 nTPM
- testis: 31 nTPM
Single-cell type
- choroid plexus epithelial cells: 585 nCPM
- early spermatids: 299 nCPM
- schwann cells: 297 nCPM
- prostatic glandular cells: 297 nCPM
- late primary spermatocytes: 211 nCPM
- fibro-adipogenic progenitors: 207 nCPM
Immune cell
- basophil: 6.7 nTPM
- neutrophil: 5.6 nTPM
- eosinophil: 5.4 nTPM
- T-reg: 3.6 nTPM
- memory CD8 T-cell: 3.4 nTPM
- memory CD4 T-cell: 3.2 nTPM
Brain region
- choroid plexus: 137 nTPM
- hypothalamus: 76 nTPM
- midbrain: 69 nTPM
- thalamus: 60 nTPM
- spinal cord: 52 nTPM
- white matter: 52 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.64
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
InteractionsUniProt · HPA
Protein binding partners of CAB39L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CAB39L as an antibody target. Whether an autoantibody or antibody against CAB39L could matter depends on whether native CAB39L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CAB39L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CAB39L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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