Seroatlas · Human Serome Atlas

CAB39

Calcium-binding protein 39

Also known as: CAB39_HUMAN, CGI-66, MO25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y376
Gene
CAB39
Ensembl
ENSG00000135932
Chromosome
2
Canonical length
341 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of protein phosphorylation. Located in cytoplasm. Part of serine/threonine protein kinase complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and pancreatic cancer. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q9Y376|CAB39
     1  MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM KEILYGTNEK
    61  EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ IFNNILRRQI GTRTPTVEYI
   121  CTQQNILFML LKGYESPEIA LNCGIMLREC IRHEPLAKII LWSEQFYDFF RYVEMSTFDI
   181  ASDAFATFKD LLTRHKLLSA EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR
   241  HNFTIMTKYI SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA
   301  KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAB39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
168 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 168 nTPM
  • tongue: 111 nTPM
  • tonsil: 53 nTPM
  • lymph node: 52 nTPM
  • esophagus: 50 nTPM
  • kidney: 50 nTPM

Single-cell type

  • neutrophils: 1,324 nCPM
  • neutrophil progenitors: 720 nCPM
  • urothelial cells: 540 nCPM
  • renal collecting duct intercalated cells: 447 nCPM
  • myonuclei: 379 nCPM
  • monocytes: 339 nCPM

Immune cell

  • neutrophil: 10 nTPM
  • NK-cell: 8.5 nTPM
  • naive CD8 T-cell: 6.5 nTPM
  • T-reg: 6.2 nTPM
  • memory CD8 T-cell: 6 nTPM
  • eosinophil: 5.8 nTPM

Brain region

  • white matter: 75 nTPM
  • cerebral cortex: 69 nTPM
  • pons: 68 nTPM
  • medulla oblongata: 66 nTPM
  • spinal cord: 65 nTPM
  • midbrain: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0.07
gnomAD missense Z
2.38
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAB39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAB39 as an antibody target. Whether an autoantibody or antibody against CAB39 could matter depends on whether native CAB39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAB39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAB39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAB39. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...