STRADB

Protein identityUniProt · HPA

UniProt accession

Q9C0K7

Gene

STRADB

Ensembl

ENSG00000082146

Chromosome

2

Canonical length

418 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Aggresome,Cytosol

OverviewNCBI Gene

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q9C0K7|STRADB
     1  MSLLDCFCTS RTQVESLRPE KQSETSIHQY LVDEPTLSWS RPSTRASEVL CSTNVSHYEL
    61  QVEIGRGFDN LTSVHLARHT PTGTLVTIKI TNLENCNEER LKALQKAVIL SHFFRHPNIT
   121  TYWTVFTVGS WLWVISPFMA YGSASQLLRT YFPEGMSETL IRNILFGAVR GLNYLHQNGC
   181  IHRSIKASHI LISGDGLVTL SGLSHLHSLV KHGQRHRAVY DFPQFSTSVQ PWLSPELLRQ
   241  DLHGYNVKSD IYSVGITACE LASGQVPFQD MHRTQMLLQK LKGPPYSPLD ISIFPQSESR
   301  MKNSQSGVDS GIGESVLVSS GTHTVNSDRL HTPSSKTFSP AFFSLVQLCL QQDPEKRPSA
   361  SSLLSHVFFK QMKEESQDSI LSLLPPAYNK PSISLPPVLP WTEPECDFPD EKDSYWEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRADB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

102 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.69

gnomAD pLI

0

gnomAD missense Z

1.54

DepMap mean gene effect

-0.22

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• activation of protein kinase activity
• cell morphogenesis
• JNK cascade
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
• protein export from nucleus

Molecular functions

• ATP binding
• protein serine/threonine kinase activator activity

Cellular components

• aggresome
• cytoplasm
• cytosol
• nucleus
• serine/threonine protein kinase complex

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Protein kinase-like domain superfamily
• STE20-related kinase adapter protein alpha/beta-like
• Protein kinase domain

KeywordsUniProt

• ATP-binding
• Cell cycle
• Cytoplasm
• Nucleotide-binding
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of STRADB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CAB39
• STK11