Seroatlas · Human Serome Atlas

WDR6

tRNA (34-2'-O)-methyltransferase regulator WDR6

Also known as: Trm734, WDR6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NNW5
Gene: WDR6
Ensembl: ENSG00000178252
Chromosome: 3
Canonical length: 1121 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

1121 residues, UniProt reviewed canonical sequence.

>Q9NNW5|WDR6
     1  MDALEDYVWP RATSELILLP VTGLECVGDR LLAGEGPDVL VYSLDFGGHL RMIKRVQNLL
    61  GHYLIHGFRV RPEPNGDLDL EAMVAVFGSK GLRVVKISWG QGHFWELWRS GLWNMSDWIW
   121  DARWLEGNIA LALGHNSVVL YDPVVGCILQ EVPCTDRCTL SSACLIGDAW KELTIVAGAV
   181  SNQLLVWYPA TALADNKPVA PDRRISGHVG IIFSMSYLES KGLLATASED RSVRIWKVGD
   241  LRVPGGRVQN IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG
   301  IRAIAAHERQ AWVITGGDDS GIRLWHLVGR GYRGLGVSAL CFKSRSRPGT LKAVTLAGSW
   361  RLLAVTDTGA LYLYDVEVKC WEQLLEDKHF QSYCLLEAAP GPEGFGLCAM ANGEGRVKVV
   421  PINTPTAAVD QTLFPGKVHS LSWALRGYEE LLLLASGPGG VVACLEISAA PSGKAIFVKE
   481  RCRYLLPPSK QRWHTCSAFL PPGDFLVCGD RRGSVLLFPS RPGLLKDPGV GGKARAGAGA
   541  PVVGSGSSGG GNAFTGLGPV STLPSLHGKQ GVTSVTCHGG YVYTTGRDGA YYQLFVRDGQ
   601  LQPVLRQKSC RGMNWLAGLR IVPDGSMVIL GFHANEFVVW NPRSHEKLHI VNCGGGHRSW
   661  AFSDTEAAMA FAYLKDGDVM LYRALGGCTR PHVILREGLH GREITCVKRV GTITLGPEYG
   721  VPSFMQPDDL EPGSEGPDLT DIVITCSEDT TVCVLALPTT TGSAHALTAV CNHISSVRAV
   781  AVWGIGTPGG PQDPQPGLTA HVVSAGGRAE MHCFSIMVTP DPSTPSRLAC HVMHLSSHRL
   841  DEYWDRQRNR HRMVKVDPET RYMSLAVCEL DQPGLGPLVA AACSDGAVRL FLLQDSGRIL
   901  QLLAETFHHK RCVLKVHSFT HEAPNQRRRL LLCSAATDGS LAFWDLTTML DHDSTVLEPP
   961  VDPGLPYRLG TPSLTLQAHS CGINSLHTLP TREGHHLVAS GSEDGSLHVF VLAVEMLQLE
  1021  EAVGEAGLVP QLRVLEEYSV PCAHAAHVTG LKILSPSIMV SASIDQRLTF WRLGHGEPTF
  1081  MNSTVFHVPD VADMDCWPVS PEFGHRCALG GQGLEVYNWY D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 173 nTPM

Expression across tissuesHPA

Tissue

ovary: 173 nTPM
pituitary gland: 155 nTPM
thyroid gland: 144 nTPM
cervix: 122 nTPM
prostate: 116 nTPM
pancreas: 115 nTPM

Single-cell type

astrocytes: 90 nCPM
pituicytes/fscs: 89 nCPM
proximal tubule cells: 84 nCPM
ependymal cells: 79 nCPM
gonadotrophs: 74 nCPM
paneth cells: 70 nCPM

Immune cell

MAIT T-cell: 18 nTPM
gdT-cell: 17 nTPM
total PBMC: 16 nTPM
intermediate monocyte: 14 nTPM
naive CD4 T-cell: 13 nTPM
plasmacytoid DC: 13 nTPM

Brain region

hypothalamus: 89 nTPM
choroid plexus: 89 nTPM
midbrain: 71 nTPM
pons: 65 nTPM
basal ganglia: 64 nTPM
cerebral cortex: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
Galactose oxidase/kelch, beta-propeller
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
tRNA Anticodon Loop Methyltransferase Regulator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR6 as an antibody target. Whether an autoantibody or antibody against WDR6 could matter depends on whether native WDR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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