STRADA

Protein identityUniProt · HPA

UniProt accession

Q7RTN6

Gene

STRADA

Ensembl

ENSG00000266173

Chromosome

17

Canonical length

431 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q7RTN6|STRADA
     1  MSFLVSKPER IRRWVSEKFI VEGLRDLELF GEQPPGDTRR KTNDASSESI ASFSKQEVMS
    61  SFLPEGGCYE LLTVIGKGFE DLMTVNLARY KPTGEYVTVR RINLEACSNE MVTFLQGELH
   121  VSKLFNHPNI VPYRATFIAD NELWVVTSFM AYGSAKDLIC THFMDGMNEL AIAYILQGVL
   181  KALDYIHHMG YVHRSVKASH ILISVDGKVY LSGLRSNLSM ISHGQRQRVV HDFPKYSVKV
   241  LPWLSPEVLQ QNLQGYDAKS DIYSVGITAC ELANGHVPFK DMPATQMLLE KLNGTVPCLL
   301  DTSTIPAEEL TMSPSRSVAN SGLSDSLTTS TPRPSNGDSP SHPYHRTFSP HFHHFVEQCL
   361  QRNPDARPSA STLLNHSFFK QIKRRASEAL PELLRPVTPI TNFEGSQSQD HSGIFGLVTN
   421  LEELEVDDWE F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRADA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

47 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STRADA.

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 446 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Polyhydramnios, megalencephaly, and symptomatic epilepsy
• Self-limited epilepsy with centrotemporal spikes

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.8

gnomAD pLI

0

gnomAD missense Z

1.49

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• activation of protein kinase activity
• G1 to G0 transition
• protein export from nucleus

Molecular functions

• ATP binding
• kinase binding
• protein kinase activator activity
• protein serine/threonine kinase activator activity

Cellular components

• cytoplasm
• cytosol
• intracellular protein-containing complex
• nucleoplasm
• nucleus
• serine/threonine protein kinase complex

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Protein kinase-like domain superfamily
• STE20-related kinase adapter protein alpha/beta-like
• Protein kinase domain

KeywordsUniProt

• ATP-binding
• Cell cycle
• Chromosomal rearrangement
• Cytoplasm
• Nucleotide-binding
• Nucleus
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of STRADA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CAB39
• STK11