Seroatlas · Human Serome Atlas

NR4A1

Nuclear receptor subfamily 4immunitygroup A member 1

Also known as: GFRP1, HMR, N10, NAK-1, NGFIB, NR4A1_HUMAN, NUR77, TR3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P22736
Gene
NR4A1
Ensembl
ENSG00000123358
Chromosome
12
Canonical length
598 aa
Protein class
Nuclear receptors, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear membrane,Nucleoli fibrillar center,Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

598 residues, UniProt reviewed canonical sequence.

>P22736|NR4A1
     1  MPCIQAQYGT PAPSPGPRDH LASDPLTPEF IKPTMDLASP EAAPAAPTAL PSFSTFMDGY
    61  TGEFDTFLYQ LPGTVQPCSS ASSSASSTSS SSATSPASAS FKFEDFQVYG CYPGPLSGPV
   121  DEALSSSGSD YYGSPCSAPS PSTPSFQPPQ LSPWDGSFGH FSPSQTYEGL RAWTEQLPKA
   181  SGPPQPPAFF SFSPPTGPSP SLAQSPLKLF PSQATHQLGE GESYSMPTAF PGLAPTSPHL
   241  EGSGILDTPV TSTKARSGAP GGSEGRCAVC GDNASCQHYG VRTCEGCKGF FKRTVQKNAK
   301  YICLANKDCP VDKRRRNRCQ FCRFQKCLAV GMVKEVVRTD SLKGRRGRLP SKPKQPPDAS
   361  PANLLTSLVR AHLDSGPSTA KLDYSKFQEL VLPHFGKEDA GDVQQFYDLL SGSLEVIRKW
   421  AEKIPGFAEL SPADQDLLLE SAFLELFILR LAYRSKPGEG KLIFCSGLVL HRLQCARGFG
   481  DWIDSILAFS RSLHSLLVDV PAFACLSALV LITDRHGLQE PRRVEELQNR IASCLKEHVA
   541  AVAGEPQPAS CLSRLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPPIIDK IFMDTLPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NR4A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
800 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 800 nTPM
  • adipose tissue: 671 nTPM
  • heart muscle: 661 nTPM
  • blood vessel: 606 nTPM
  • adrenal gland: 530 nTPM
  • fallopian tube: 454 nTPM

Single-cell type

  • epicardial cells: 1,492 nCPM
  • ovarian stromal cells: 1,173 nCPM
  • endometrial luminal cells: 1,029 nCPM
  • vascular smooth muscle cells: 825 nCPM
  • breast secretory cells: 821 nCPM
  • smooth muscle cells: 703 nCPM

Immune cell

  • non-classical monocyte: 54 nTPM
  • intermediate monocyte: 37 nTPM
  • myeloid DC: 3.7 nTPM
  • total PBMC: 2 nTPM
  • classical monocyte: 1.3 nTPM
  • memory B-cell: 0.9 nTPM

Brain region

  • cerebellum: 288 nTPM
  • cerebral cortex: 165 nTPM
  • choroid plexus: 96 nTPM
  • hypothalamus: 63 nTPM
  • medulla oblongata: 49 nTPM
  • white matter: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.37
gnomAD missense Z
1.51
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NR4A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NR4A1 as an antibody target. Whether an autoantibody or antibody against NR4A1 could matter depends on whether native NR4A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NR4A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NR4A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NR4A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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