STK11IP

Protein identityUniProt · HPA

UniProt accession

Q8N1F8

Gene

STK11IP

Ensembl

ENSG00000144589

Chromosome

2

Canonical length

1088 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles

OverviewNCBI Gene

Enables protein kinase binding activity. Involved in protein localization. Located in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1088 residues, UniProt reviewed canonical sequence.

>Q8N1F8|STK11IP
     1  MTTAQRDSLL WKLAGLLRES GDVVLSGCST LSLLTPTLQQ LNHVFELHLG PWGPGQTGFV
    61  ALPSHPADSP VILQLQFLFD VLQKTLSLKL VHVAGPGPTG PIKIFPFKSL RHLELRGVPL
   121  HCLHGLRGIY SQLETLICSR SLQALEELLS ACGGDFCSAL PWLALLSANF SYNALTALDS
   181  SLRLLSALRF LNLSHNQVQD CQGFLMDLCE LHHLDISYNR LHLVPRMGPS GAALGVLILR
   241  GNELRSLHGL EQLRNLRHLD LAYNLLEGHR ELSPLWLLAE LRKLYLEGNP LWFHPEHRAA
   301  TAQYLSPRAR DAATGFLLDG KVLSLTDFQT HTSLGLSPMG PPLPWPVGST PETSGGPDLS
   361  DSLSSGGVVT QPLLHKVKSR VRVRRASISE PSDTDPEPRT LNPSPAGWFV QQHPELELMS
   421  SFRERFGRNW LQYRSHLEPS GNPLPATPTT SAPSAPPASS QGPDTAPRPS PPQEEARGPQ
   481  ESPQKMSEEV RAEPQEEEEE KEGKEEKEEG EMVEQGEEEA GEEEEEEQDQ KEVEAELCRP
   541  LLVCPLEGPE GVRGRECFLR VTSAHLFEVE LQAARTLERL ELQSLEAAEI EPEAQAQRSP
   601  RPTGSDLLPG APILSLRFSY ICPDRQLRRY LVLEPDAHAA VQELLAVLTP VTNVAREQLG
   661  EARDLLLGRF QCLRCGHEFK PEEPRMGLDS EEGWRPLFQK TESPAVCPNC GSDHVVLLAV
   721  SRGTPNRERK QGEQSLAPSP SASPVCHPPG HGDHLDRAKN SPPQAPSTRD HGSWSLSPPP
   781  ERCGLRSVDH RLRLFLDVEV FSDAQEEFQC CLKVPVALAG HTGEFMCLVV VSDRRLYLLK
   841  VTGEMREPPA SWLQLTLAVP LQDLSGIELG LAGQSLRLEW AAGAGRCVLL PRDARHCRAF
   901  LEELLDVLQS LPPAWRNCVS ATEEEVTPQH RLWPLLEKDS SLEARQFFYL RAFLVEGPST
   961  CLVSLLLTPS TLFLLDEDAA GSPAEPSPPA ASGEASEKVP PSGPGPAVRV REQQPLSSLS
  1021  SVLLYRSAPE DLRLLFYDEV SRLESFWALR VVCQEQLTAL LAWIREPWEE LFSIGLRTVI
  1081  QEALALDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK11IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

30 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.86

gnomAD pLI

0

gnomAD missense Z

0.51

DepMap mean gene effect

0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intracellular protein localization

Molecular functions

• protein kinase binding

Cellular components

• azurophil granule lumen
• cytoplasm
• extracellular region
• lysosomal membrane

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• Leucine-rich repeat domain superfamily
• PLEKHM2, PH domain-like
• PLEKHM2 PH domain-like
• LKB1 serine/threonine kinase interacting protein 1, N-terminal
• Serine/threonine-protein kinase 11-interacting protein, PH domain
• STK11-interacting protein, C-terminal PH domain
• LKB1 serine/threonine kinase interacting protein 1
• STK11-interacting protein PH domain
• STK11-interacting protein, C-terminal PH domain

KeywordsUniProt

• Cytoplasm
• Leucine-rich repeat
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of STK11IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SMAD4
• STK11