Seroatlas · Human Serome Atlas

CWF19L2

CWF19-like protein 2

Also known as: C19L2_HUMAN, FLJ32343

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TBE0
Gene: CWF19L2
Ensembl: ENSG00000152404
Chromosome: 11
Canonical length: 894 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of post-mRNA release spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

894 residues, UniProt reviewed canonical sequence.

>Q2TBE0|CWF19L2
     1  MATSMAAASG RFESAKSIEE RKEQTRNARA EVLRQAKANF EKEERRKELK RLRGEDTWML
    61  PDVNERIEQF SQEHSVKKKK KKDKHSKKAK KEKKKKSKKQ KYEKNNESSD SSSSSEDEWV
   121  EAVPSQTPDK EKAWKVKDEK SGKDDTQIIK RDEWMTVDFM SVKTVSSSSL KAEKETMRKI
   181  EQEKNQALEQ SKLMERELNP YWKDGGTGLP PEDCSVSSIT KVSVVEDGGL SWLRKSYLRM
   241  KEQAEKQSRN FEDIVAERYG SMEIFQSKLE DAEKAASTKE DYRRERWRKP TYSDKAQNCQ
   301  ESRESDLVKY GNSSRDRYAT TDTAKNSNNE KFIGDEKDKR PGSLETCRRE SNPRQNQEFS
   361  FGNLRAKFLR PSDDEELSFH SKGRKFEPLS SSSALVAQGS LCSGFRKPTK NSEERLTSWS
   421  RSDGRGDKKH SNQKPSETST DEHQHVPEDP REKSQDEVLR DDPPKKEHLR DTKSTFAGSP
   481  ERESIHILSV DEKNKLGAKI IKAEMMGNME LAEQLKVQLE KANKFKETIT QIPKKSGVEN
   541  EDQQEVILVR TDQSGRVWPV NTPGKSLESQ GGRRKRQMVS THEERERVRY FHDDDNLSLN
   601  DLVKNEKMGT AENQNKLFMR MASKFMGKTD GDYYTLDDMF VSKAAERERL GEEEENQRKK
   661  AIAEHRSLAA QMEKCLYCFD SSQFPKHLIV AIGVKVYLCL PNVRSLTEGH CLIVPLQHHR
   721  AATLLDEDIW EEIQMFRKSL VKMFEDKGLD CIFLETNMSM KKQYHMVYEC IPLPKEVGDM
   781  APIYFKKAIM ESDEEWSMNK KLIDLSSKDI RKSVPRGLPY FSVDFGLHGG FAHVIEDQHK
   841  FPHYFGKEII GGMLDIEPRL WRKGIRESFE DQRKKALQFA QWWKPYDFTK SKNY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CWF19L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 16 nTPM
ovary: 12 nTPM
thymus: 11 nTPM
breast: 11 nTPM
kidney: 11 nTPM
tonsil: 11 nTPM

Single-cell type

adrenal cortex cells: 167 nCPM
b-cells: 146 nCPM
proximal tubule cells: 139 nCPM
myonuclei: 134 nCPM
corticotrophs: 128 nCPM
t-cells: 125 nCPM

Immune cell

basophil: 46 nTPM
memory B-cell: 30 nTPM
naive B-cell: 28 nTPM
naive CD4 T-cell: 20 nTPM
neutrophil: 20 nTPM
eosinophil: 20 nTPM

Brain region

cerebellum: 26 nTPM
white matter: 19 nTPM
choroid plexus: 18 nTPM
hypothalamus: 18 nTPM
basal ganglia: 17 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -0.38
DepMap mean gene effect: -0.52
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CWF19L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CWF19L2 as an antibody target. Whether an autoantibody or antibody against CWF19L2 could matter depends on whether native CWF19L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CWF19L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CWF19L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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