ATP1B4

Protein identityUniProt · HPA

UniProt accession

Q9UN42

Gene

ATP1B4

Ensembl

ENSG00000101892

Chromosome

X

Canonical length

357 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q9UN42|ATP1B4
     1  MRRQLRSRRA PSFPYSYRYR LDDPDEANQN YLADEEEEAE EEARVTVVPK SEEEEEEEEK
    61  EEEEEEEKEE EEGQGQPTGN AWWQKLQIMS EYLWDPERRM FLARTGQSWS LILLIYFFFY
   121  ASLAAVITLC MYTLFLTISP YIPTFTERVK PPGVMIRPFA HSLNFNFNVS EPDTWQHYVI
   181  SLNGFLQGYN DSLQEEMNVD CPPGQYFIQD GNEDEDKKAC QFKRSFLKNC SGLEDPTFGY
   241  STGQPCILLK MNRIVGFRPE LGDPVKVSCK VQRGDENDIR SISYYPESAS FDLRYYPYYG
   301  KLTHVNYTSP LVAMHFTDVV KNQAVPVQCQ LKGKGVINDV INDRFVGRVI FTLNIET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP1B4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

52 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.92

gnomAD pLI

0

gnomAD missense Z

0.22

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• potassium ion transport
• regulation of DNA-templated transcription
• sodium ion transport

Molecular functions

• inorganic cation transmembrane transporter activity

Cellular components

• nuclear envelope
• nuclear inner membrane
• plasma membrane
• sodium:potassium-exchanging ATPase complex

Protein domainsUniProt · Pfam · InterPro

• Sodium/potassium-transporting ATPase subunit beta
• Sodium/potassium-transporting ATPase subunit beta superfamily
• Sodium / potassium ATPase beta chain

KeywordsUniProt

• Membrane
• Nucleus
• Signal-anchor
• Transcription
• Transcription regulation
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ATP1B4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SNW1
• TOR1AIP1