Seroatlas · Human Serome Atlas

PRMT7

Protein arginine N-methyltransferase 7

Also known as: ANM7_HUMAN, FLJ10640, KIAA1933

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVM4
Gene
PRMT7
Ensembl
ENSG00000132600
Chromosome
16
Canonical length
692 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

692 residues, UniProt reviewed canonical sequence.

>Q9NVM4|PRMT7
     1  MKIFCSRANP TTGSVEWLEE DEHYDYHQEI ARSSYADMLH DKDRNVKYYQ GIRAAVSRVK
    61  DRGQKALVLD IGTGTGLLSM MAVTAGADFC YAIEVFKPMA DAAVKIVEKN GFSDKIKVIN
   121  KHSTEVTVGP EGDMPCRANI LVTELFDTEL IGEGALPSYE HAHRHLVEEN CEAVPHRATV
   181  YAQLVESGRM WSWNKLFPIH VQTSLGEQVI VPPVDVESCP GAPSVCDIQL NQVSPADFTV
   241  LSDVLPMFSI DFSKQVSSSA ACHSRRFEPL TSGRAQVVLS WWDIEMDPEG KIKCTMAPFW
   301  AHSDPEEMQW RDHWMQCVYF LPQEEPVVQG SALYLVAHHD DYCVWYSLQR TSPEKNERVR
   361  QMRPVCDCQA HLLWNRPRFG EINDQDRTDR YVQALRTVLK PDSVCLCVSD GSLLSVLAHH
   421  LGVEQVFTVE SSAASHKLLR KIFKANHLED KINIIEKRPE LLTNEDLQGR KVSLLLGEPF
   481  FTTSLLPWHN LYFWYVRTAV DQHLGPGAMV MPQAASLHAV VVEFRDLWRI RSPCGDCEGF
   541  DVHIMDDMIK RALDFRESRE AEPHPLWEYP CRSLSEPWQI LTFDFQQPVP LQPLCAEGTV
   601  ELRRPGQSHA AVLWMEYHLT PECTLSTGLL EPADPEGGCC WNPHCKQAVY FFSPAPDPRA
   661  LLGGPRTVSY AVEFHPDTGD IIMEFRHADT PD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRMT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 13 nTPM
  • thymus: 10 nTPM
  • skeletal muscle: 9.9 nTPM
  • basal ganglia: 7.9 nTPM
  • cerebral cortex: 7.3 nTPM
  • heart muscle: 6.9 nTPM

Single-cell type

  • epicardial cells: 280 nCPM
  • myonuclei: 109 nCPM
  • pdcs: 83 nCPM
  • choroid plexus epithelial cells: 69 nCPM
  • cone photoreceptor cells: 64 nCPM
  • adipocytes: 61 nCPM

Immune cell

  • plasmacytoid DC: 30 nTPM
  • NK-cell: 22 nTPM
  • MAIT T-cell: 21 nTPM
  • naive CD4 T-cell: 18 nTPM
  • gdT-cell: 18 nTPM
  • naive CD8 T-cell: 16 nTPM

Brain region

  • choroid plexus: 4.9 nTPM
  • cerebral cortex: 2.8 nTPM
  • pons: 2.8 nTPM
  • basal ganglia: 2.6 nTPM
  • cerebellum: 2.6 nTPM
  • spinal cord: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRMT7.

Disease | AllUniProt

Conditions PRMT7 is implicated in, by any mechanism.

  • Short stature, brachydactyly, impaired intellectual developmental, and seizures (SBIDDS) MIM:617157

Disease | GeneticClinVar

46 pathogenic / likely-pathogenic of 371 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRMT7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRMT7 as an antibody target. Whether an autoantibody or antibody against PRMT7 could matter depends on whether native PRMT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRMT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRMT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRMT7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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