RRT5/SRSF/Splicing Factor SR

Definition

The RRT5/SRSF/Splicing Factor SR family is involved in various aspects of RNA processing, including pre-mRNA splicing, rDNA transcription modulation, and mRNA export. Members of this family play roles in constitutive and alternative splicing, ensuring the accuracy of splicing and regulating splice site selection. Some proteins within this family are implicated in cell cycle progression, spermatogenesis, and response to oxidative stress. Others are involved in ribosome assembly and pre-rRNA processing, contributing to the maintenance of ribosomal subunit levels. The family includes proteins with RNA recognition motifs (RRMs) and serine/arginine-rich (SR) domains, which are characteristic of splicing factors and are essential for spliceosome assembly and function. The family's diverse functions reflect its members' involvement in critical cellular processes, including gene expression regulation, development, and response to cellular stress.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• HNRNPM
• MYEF2
• SF3B6
• SRSF1
• SRSF4
• SRSF5
• SRSF6
• SRSF9