Seroatlas · Human Serome Atlas

STAMBP

STAM-binding protein

Also known as: AMSH, STABP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95630
Gene
STAMBP
Ensembl
ENSG00000124356
Chromosome
2
Canonical length
424 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>O95630|STAMBP
     1  MSDHGDVSLP PEDRVRALSQ LGSAVEVNED IPPRRYFRSG VEIIRMASIY SEEGNIEHAF
    61  ILYNKYITLF IEKLPKHRDY KSAVIPEKKD TVKKLKEIAF PKAEELKAEL LKRYTKEYTE
   121  YNEEKKKEAE ELARNMAIQQ ELEKEKQRVA QQKQQQLEQE QFHAFEEMIR NQELEKERLK
   181  IVQEFGKVDP GLGGPLVPDL EKPSLDVFPT LTVSSIQPSD CHTTVRPAKP PVVDRSLKPG
   241  ALSNSESIPT IDGLRHVVVP GRLCPQFLQL ASANTARGVE TCGILCGKLM RNEFTITHVL
   301  IPKQSAGSDY CNTENEEELF LIQDQQGLIT LGWIHTHPTQ TAFLSSVDLH THCSYQMMLP
   361  ESVAIVCSPK FQETGFFKLT DHGLEEISSC RQKGFHPHSK DPPLFCSCSH VTVVDRAVTI
   421  TDLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAMBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 28 nTPM
  • tongue: 24 nTPM
  • duodenum: 16 nTPM
  • rectum: 16 nTPM
  • esophagus: 16 nTPM
  • parathyroid gland: 16 nTPM

Single-cell type

  • esophageal apical cells: 229 nCPM
  • late spermatids: 212 nCPM
  • megakaryocytes: 111 nCPM
  • esophageal suprabasal cells: 110 nCPM
  • myonuclei: 106 nCPM
  • oligodendrocytes: 85 nCPM

Immune cell

  • eosinophil: 27 nTPM
  • basophil: 25 nTPM
  • T-reg: 21 nTPM
  • neutrophil: 21 nTPM
  • intermediate monocyte: 20 nTPM
  • memory B-cell: 19 nTPM

Brain region

  • white matter: 31 nTPM
  • medulla oblongata: 23 nTPM
  • basal ganglia: 22 nTPM
  • cerebellum: 21 nTPM
  • spinal cord: 20 nTPM
  • pons: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STAMBP.

Disease | AllUniProt

Conditions STAMBP is implicated in, by any mechanism.

  • Microcephaly-capillary malformation syndrome (MICCAP) MIM:614261

Disease | GeneticClinVar

27 pathogenic / likely-pathogenic of 251 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0
gnomAD missense Z
0.89
DepMap mean gene effect
-0.43
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAMBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAMBP as an antibody target. Whether an autoantibody or antibody against STAMBP could matter depends on whether native STAMBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAMBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAMBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STAMBP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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