Seroatlas · Human Serome Atlas

UBE2E1

Ubiquitin-conjugating enzyme E2 E1

Also known as: UB2E1_HUMAN, UbcH6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51965
Gene: UBE2E1
Ensembl: ENSG00000170142
Chromosome: 3
Canonical length: 193 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>P51965|UBE2E1
     1  MSDDDSRAST SSSSSSSSNQ QTEKETNTPK KKESKVSMSK NSKLLSTSAK RIQKELADIT
    61  LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI TFTPEYPFKP PKVTFRTRIY
   121  HCNINSQGVI CLDILKDNWS PALTISKVLL SICSLLTDCN PADPLVGSIA TQYMTNRAEH
   181  DRMARQWTKR YAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 116 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 116 nTPM
spinal cord: 105 nTPM
tonsil: 101 nTPM
parathyroid gland: 97 nTPM
midbrain: 96 nTPM
lymph node: 96 nTPM

Single-cell type

esophageal apical cells: 377 nCPM
monocytes: 334 nCPM
microglia: 326 nCPM
neutrophil progenitors: 279 nCPM
sertoli cells: 273 nCPM
neutrophils: 268 nCPM

Immune cell

intermediate monocyte: 4.7 nTPM
NK-cell: 4.3 nTPM
classical monocyte: 4.2 nTPM
plasmacytoid DC: 4 nTPM
myeloid DC: 3.8 nTPM
eosinophil: 3.7 nTPM

Brain region

white matter: 92 nTPM
hypothalamus: 81 nTPM
medulla oblongata: 78 nTPM
spinal cord: 77 nTPM
cerebellum: 74 nTPM
pons: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.71
gnomAD missense Z: 1.99
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2E1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2E1 as an antibody target. Whether an autoantibody or antibody against UBE2E1 could matter depends on whether native UBE2E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2E1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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