Seroatlas · Human Serome Atlas

RPH3AL

Rab effector Noc2

Also known as: Noc2, RPH3L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNE2
Gene: RPH3AL
Ensembl: ENSG00000181031
Chromosome: 17
Canonical length: 315 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q9UNE2|RPH3AL
     1  MADTIFGSGN DQWVCPNDRQ LALRAKLQTG WSVHTYQTEK QRRKQHLSPA EVEAILQVIQ
    61  RAERLDVLEQ QRIGRLVERL ETMRRNVMGN GLSQCLLCGE VLGFLGSSSV FCKDCRKKVC
   121  TKCGIEASPG QKRPLWLCKI CSEQREVWKR SGAWFYKGLP KYILPLKTPG RADDPHFRPL
   181  PTEPAEREPR SSETSRIYTW ARGRVVSSDS DSDSDLSSSS LEDRLPSTGV RDRKGDKPWK
   241  ESGGSVEAPR MGFTHPPGHL SGCQSSLASG ETGTGSADPP GGPRPGLTRR APVKDTPGRA
   301  PAADAAPAGP SSCLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPH3AL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

pancreas: 50 nTPM
pituitary gland: 42 nTPM
liver: 23 nTPM
adrenal gland: 17 nTPM
spleen: 17 nTPM
kidney: 14 nTPM

Single-cell type

renal collecting duct principal cells: 151 nCPM
renal connecting tubule cells: 138 nCPM
papillary tip epithelial cells: 91 nCPM
renal collecting duct intercalated cells: 82 nCPM
podocytes: 74 nCPM
loop of henle epithelial cells: 63 nCPM

Immune cell

plasmacytoid DC: 2.8 nTPM
intermediate monocyte: 2.2 nTPM
non-classical monocyte: 1.8 nTPM
neutrophil: 1.6 nTPM
eosinophil: 1.5 nTPM
myeloid DC: 1.1 nTPM

Brain region

pons: 10 nTPM
cerebellum: 7.8 nTPM
medulla oblongata: 7.6 nTPM
hypothalamus: 5.3 nTPM
midbrain: 4.8 nTPM
white matter: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: -0.31
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPH3AL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPH3AL as an antibody target. Whether an autoantibody or antibody against RPH3AL could matter depends on whether native RPH3AL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPH3AL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPH3AL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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