REP15
Rab15 effector protein
Also known as: RAB15EP, REP15_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6BDI9
- Gene
- REP15
- Ensembl
- ENSG00000174236
- Chromosome
- 12
- Canonical length
- 236 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
The protein encoded by this intronless gene interacts with GTP-bound Rab15 and is involved in recycling of transferrin receptor from the endocytic recycling compartment to the cell surface. [provided by RefSeq, Sep 2016]
Canonical amino-acid sequenceUniProt
236 residues, UniProt reviewed canonical sequence.
>Q6BDI9|REP15
1 MGQKASQQLA LKDSKEVPVV CEVVSEAIVH AAQKLKEYLG FEYPPSKLCP AANTLNEIFL
61 IHFITFCQEK GVDEWLTTTK MTKHQAFLFG ADWIWTFWGS NKQIKLQLAV QTLQMSSPPP
121 VESKPCDLSN PESRVEESSW KKSRFDKLEE FCNLIGEDCL GLFIIFGMPG KPKDIRGVVL
181 DSVKSQMVRS HLPGGKAVAQ FVLETEDCVF IKELLRNCLS KKDGLREVGK VYISILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against REP15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 73 nTPM
Expression across tissuesHPA
Tissue
- stomach: 73 nTPM
- rectum: 56 nTPM
- colon: 35 nTPM
- small intestine: 30 nTPM
- duodenum: 13 nTPM
- heart muscle: 5.2 nTPM
Single-cell type
- goblet cells: 562 nCPM
- foveolar cells: 103 nCPM
- lymphatic endothelial cells: 13 nCPM
- mucous neck cells: 8.2 nCPM
- epididymal basal cells: 6.8 nCPM
- proximal tubule cells: 5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 3.7 nTPM
- hippocampal formation: 3.4 nTPM
- thalamus: 3.4 nTPM
- amygdala: 3 nTPM
- white matter: 2.6 nTPM
- choroid plexus: 2.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.78
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.44
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Rab15 effector
- Rab15 effector
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of REP15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads REP15 as an antibody target. Whether an autoantibody or antibody against REP15 could matter depends on whether native REP15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
REP15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label REP15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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