Seroatlas · Human Serome Atlas

ARL6IP5

PRA1 family protein 3

Also known as: DERP11, GTRAP3-18, HSPC127, JWA, PRAF3, PRAF3_HUMAN, Yip6b

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75915
Gene: ARL6IP5
Ensembl: ENSG00000144746
Chromosome: 3
Canonical length: 188 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum
Quaternary structure: Homodimer

OverviewNCBI Gene

Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>O75915|ARL6IP5
     1  MDVNIAPLRA WDDFFPGSDR FARPDFRDIS KWNNRVVSNL LYYQTNYLVV AAMMISIVGF
    61  LSPFNMILGG IVVVLVFTGF VWAAHNKDVL RRMKKRYPTT FVMVVMLASY FLISMFGGVM
   121  VFVFGITFPL LLMFIHASLR LRNLKNKLEN KMEGIGLKRT PMGIVLDALE QQEEGINRLT
   181  DYISKVKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL6IP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 203 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 203 nTPM
tongue: 174 nTPM
skeletal muscle: 172 nTPM
blood vessel: 163 nTPM
salivary gland: 151 nTPM
adipose tissue: 148 nTPM

Single-cell type

platelets: 1,165 nCPM
salivary ionocytes: 565 nCPM
extravillous trophoblasts: 523 nCPM
breast lactating cells: 481 nCPM
cytotrophoblasts: 370 nCPM
neutrophils: 349 nCPM

Immune cell

total PBMC: 932 nTPM
basophil: 698 nTPM
eosinophil: 651 nTPM
T-reg: 532 nTPM
memory CD4 T-cell: 464 nTPM
memory CD8 T-cell: 427 nTPM

Brain region

white matter: 119 nTPM
pons: 104 nTPM
hypothalamus: 103 nTPM
spinal cord: 100 nTPM
cerebellum: 92 nTPM
medulla oblongata: 89 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0.1
gnomAD missense Z: 0.37
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL6IP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL6IP5 as an antibody target. Whether an autoantibody or antibody against ARL6IP5 could matter depends on whether native ARL6IP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL6IP5 is annotated at the cell surface, where native ARL6IP5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARL6IP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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