Seroatlas · Human Serome Atlas

RAB3IP

Rab-3A-interacting protein

Also known as: FLJ22548, RAB3I_HUMAN, RABIN3, RABIN8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96QF0
Gene
RAB3IP
Ensembl
ENSG00000127328
Chromosome
12
Canonical length
476 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity and identical protein binding activity. Involved in several processes, including positive regulation of cilium assembly; protein localization to motile cilium; and protein targeting to membrane. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q96QF0|RAB3IP
     1  MGLKKMKGLS YDEAFAMAND PLEGFHEVNL ASPTSPDLLG VYESGTQEQT TSPSVIYRPH
    61  PSALSSVPIQ ANALDVSELP TQPVYSSPRR LNCAEISSIS FHVTDPAPCS TSGVTAGLTK
   121  LTTRKDNYNA EREFLQGATI TEACDGSDDI FGLSTDSLSR LRSPSVLEVR EKGYERLKEE
   181  LAKAQRELKL KDEECERLSK VRDQLGQELE ELTASLFEEA HKMVREANIK QATAEKQLKE
   241  AQGKIDVLQA EVAALKTLVL SSSPTSPTQE PLPGGKTPFK KGHTRNKSTS SAMSGSHQDL
   301  SVIQPIVKDC KEADLSLYNE FRLWKDEPTM DRTCPFLDKI YQEDIFPCLT FSKSELASAV
   361  LEAVENNTLS IEPVGLQPIR FVKASAVECG GPKKCALTGQ SKSCKHRIKL GDSSNYYYIS
   421  PFCRYRITSV CNFFTYIRYI QQGLVKQQDV DQMFWEVMQL RKEMSLAKLG YFKEEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB3IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 110 nTPM
  • retina: 82 nTPM
  • testis: 70 nTPM
  • kidney: 45 nTPM
  • epididymis: 42 nTPM
  • cerebellum: 32 nTPM

Single-cell type

  • late spermatids: 475 nCPM
  • choroid plexus epithelial cells: 316 nCPM
  • retinal pigment epithelial cells: 230 nCPM
  • early spermatids: 219 nCPM
  • epididymal clear cells: 182 nCPM
  • endometrial glandular cells: 181 nCPM

Immune cell

  • T-reg: 13 nTPM
  • naive CD4 T-cell: 9.4 nTPM
  • memory B-cell: 9.3 nTPM
  • naive CD8 T-cell: 9.2 nTPM
  • naive B-cell: 8.7 nTPM
  • MAIT T-cell: 8.5 nTPM

Brain region

  • cerebellum: 180 nTPM
  • choroid plexus: 123 nTPM
  • pons: 68 nTPM
  • white matter: 65 nTPM
  • medulla oblongata: 63 nTPM
  • midbrain: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.67
DepMap mean gene effect
-0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB3IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB3IP as an antibody target. Whether an autoantibody or antibody against RAB3IP could matter depends on whether native RAB3IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB3IP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB3IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB3IP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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