Seroatlas · Human Serome Atlas

GTF3C4

General transcription factor 3C polypeptide 4

Also known as: KAT12, TF3C4_HUMAN, TFIIIC90

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKN8
Gene
GTF3C4
Ensembl
ENSG00000125484
Chromosome
9
Canonical length
822 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables RNA polymerase III general transcription initiation factor activity and histone H3K14 acetyltransferase activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III; tRNA transcription by RNA polymerase III; and transcription initiation at RNA polymerase III promoter. Located in mitochondrion and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

822 residues, UniProt reviewed canonical sequence.

>Q9UKN8|GTF3C4
     1  MNTADQARVG PADDGPAPSG EEEGEGGGEA GGKEPAADAA PGPSAAFRLM VTRREPAVKL
    61  QYAVSGLEPL AWSEDHRVSV STARSIAVLE LICDVHNPGQ DLVIHRTSVP APLNSCLLKV
   121  GSKTEVAECK EKFAASKDPT VSQTFMLDRV FNPEGKALPP MRGFKYTSWS PMGCDANGRC
   181  LLAALTMDNR LTIQANLNRL QWVQLVDLTE IYGERLYETS YRLSKNEAPE GNLGDFAEFQ
   241  RRHSMQTPVR MEWSGICTTQ QVKHNNECRD VGSVLLAVLF ENGNIAVWQF QLPFVGKESI
   301  SSCNTIESGI TSPSVLFWWE YEHNNRKMSG LIVGSAFGPI KILPVNLKAV KGYFTLRQPV
   361  ILWKEMDQLP VHSIKCVPLY HPYQKCSCSL VVAARGSYVF WCLLLISKAG LNVHNSHVTG
   421  LHSLPIVSMT ADKQNGTVYT CSSDGKVRQL IPIFTDVALK FEHQLIKLSD VFGSVRTHGI
   481  AVSPCGAYLA IITTEGMING LHPVNKNYQV QFVTLKTFEE AAAQLLESSV QNLFKQVDLI
   541  DLVRWKILKD KHIPQFLQEA LEKKIESSGV TYFWRFKLFL LRILYQSMQK TPSEALWKPT
   601  HEDSKILLVD SPGMGNADDE QQEEGTSSKQ VVKQGLQERS KEGDVEEPTD DSLPTTGDAG
   661  GREPMEEKLL EIQGKIEAVE MHLTREHMKR VLGEVYLHTW ITENTSIPTR GLCNFLMSDE
   721  EYDDRTARVL IGHISKKMNK QTFPEHCSLC KEILPFTDRK QAVCSNGHIW LRCFLTYQSC
   781  QSLIYRRCLL HDSIARHPAP EDPDWIKRLL QSPCPFCDSP VF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTF3C4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
9.3 nTPM

Expression across tissuesHPA

Tissue

  • skin: 9.3 nTPM
  • parathyroid gland: 8.9 nTPM
  • thyroid gland: 8.9 nTPM
  • cerebellum: 8.5 nTPM
  • ovary: 8.4 nTPM
  • breast: 7.9 nTPM

Single-cell type

  • suprabasal keratinocytes: 39 nCPM
  • basal keratinocytes: 38 nCPM
  • erythrocyte progenitors: 37 nCPM
  • endometrial ciliated cells: 32 nCPM
  • salivary basal cells: 29 nCPM
  • leydig cells: 28 nCPM

Immune cell

  • memory CD8 T-cell: 0.6 nTPM
  • gdT-cell: 0.5 nTPM
  • memory B-cell: 0.5 nTPM
  • naive CD4 T-cell: 0.5 nTPM
  • naive CD8 T-cell: 0.5 nTPM
  • NK-cell: 0.5 nTPM

Brain region

  • cerebellum: 24 nTPM
  • hypothalamus: 16 nTPM
  • midbrain: 15 nTPM
  • basal ganglia: 15 nTPM
  • hippocampal formation: 14 nTPM
  • cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.26
gnomAD missense Z
2.42
DepMap mean gene effect
-0.6
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • WD40-repeat-containing domain superfamily
  • Transcription factor IIIC, 90kDa subunit, N-terminal
  • Transcription factor IIIC, putative zinc-finger
  • General transcription factor 3C polypeptide 4
  • Domain of unknown function DUF5921
  • Transcription factor IIIC subunit delta bet-propeller domain
  • Putative zinc-finger of transcription factor IIIC complex
  • Domain of unknown function (DUF5921)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GTF3C4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTF3C4 as an antibody target. Whether an autoantibody or antibody against GTF3C4 could matter depends on whether native GTF3C4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTF3C4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTF3C4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GTF3C4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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