Seroatlas · Human Serome Atlas

ARMH3

Armadillo-like helical domain-containing protein 3

Also known as: ARMD3_HUMAN, C10orf76, FLJ13114

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T2E6
Gene: ARMH3
Ensembl: ENSG00000120029
Chromosome: 10
Canonical length: 689 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Involved in regulation of Golgi organization. Located in Golgi membrane and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

689 residues, UniProt reviewed canonical sequence.

>Q5T2E6|ARMH3
     1  MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF LMKVNLEYLE
    61  GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA LQTLCALIRG VHQKNKSTSG
   121  FDIINMLMGF DKAELCMKNL MESLDSLLCA EGSESLKSLC LKLLLCLVTV TDNISQNTIL
   181  EYVMINSIFE AILQILSHPP SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT
   241  LNGMGLVIAQ ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKI SVQTNEAILL
   301  ALYEAVHLNR NFITVLAQSH PEMGLVTTPV SPAPTTPVTP LGTTPPSSDV ISSVELPLDA
   361  DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC IAEDQYANAF LHDDNMNFRV
   421  NLHRMPMRHR KKAADKNLPC RPLVCAVLDL MVEFIVTHMM KEFPMDLYIR CIQVVHKLLC
   481  YQKKCRVRLH YTWRELWSAL INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT
   541  FLPTPSSYDE LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF
   601  NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH KEAAFFKELV
   661  RSISTNVRRN LAFHTLSQEV LLKEFSTIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 21 nTPM
tongue: 19 nTPM
skeletal muscle: 19 nTPM
heart muscle: 16 nTPM
parathyroid gland: 15 nTPM
retina: 15 nTPM

Single-cell type

myonuclei: 357 nCPM
cone photoreceptor cells: 273 nCPM
adipocytes: 268 nCPM
microglia: 225 nCPM
neutrophil progenitors: 209 nCPM
cardiomyocytes: 195 nCPM

Immune cell

basophil: 20 nTPM
non-classical monocyte: 11 nTPM
intermediate monocyte: 8.7 nTPM
myeloid DC: 7.7 nTPM
eosinophil: 7.5 nTPM
plasmacytoid DC: 7.4 nTPM

Brain region

cerebellum: 33 nTPM
midbrain: 30 nTPM
choroid plexus: 29 nTPM
basal ganglia: 28 nTPM
white matter: 27 nTPM
hypothalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-type fold
Armadillo-like helical domain-containing protein 3, C-terminal
Armadillo-like helical domain-containing protein 3-like
Armadillo-like helical domain-containing protein 3, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMH3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMH3 as an antibody target. Whether an autoantibody or antibody against ARMH3 could matter depends on whether native ARMH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMH3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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