Seroatlas · Human Serome Atlas

ATG9A

Autophagy-related protein 9A

Also known as: APG9L1, ATG9A_HUMAN, FLJ22169

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z3C6
Gene
ATG9A
Ensembl
ENSG00000198925
Chromosome
2
Canonical length
839 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Vesicles
Quaternary structure
Homotrimer

OverviewNCBI Gene

Enables phospholipid scramblase activity. Involved in autophagosome assembly. Located in several cellular components, including Golgi apparatus; endosome; and phagophore assembly site. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

839 residues, UniProt reviewed canonical sequence.

>Q7Z3C6|ATG9A
     1  MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV YNLHQKNGFT
    61  CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH SLHPTEPVKV TLPDAFLPAQ
   121  VCSARIQENG SLITILVIAG VFWIHRLIKF IYNICCYWEI HSFYLHALRI PMSALPYCTW
   181  QEVQARIVQT QKEHQICIHK RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEA
   241  VFFTRGLKYN FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL
   301  CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL QSRLNRGYKP
   361  ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED VLAVEHVLTT VTLLGVTVTV
   421  CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL
   481  LSPIVTPLIL IFCLRPRALE IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSAGQT
   541  EASVYQQAED GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA ASLAQGGLLP
   601  ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLPRDLQ GSRHRAEVAS ALRSFSPLQP
   661  GQAPTGRAHS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE YASTEMSLHA LYMHQLHKQQ
   721  AQAEPERHVW HRRESDESGE SAPDEGGEGA RAPQSIPRSA SYPCAAPRPG APETTALHGG
   781  FQRRYGGITD PGTVPRVPSH FSRLPLGGWA EDGQSASRHP EPVPEEGSED ELPPQVHKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATG9A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
136 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 136 nTPM
  • testis: 62 nTPM
  • tongue: 59 nTPM
  • heart muscle: 48 nTPM
  • cerebellum: 44 nTPM
  • bone marrow: 42 nTPM

Single-cell type

  • tuft cells: 46 nCPM
  • oligodendrocytes: 18 nCPM
  • brain inhibitory neurons: 18 nCPM
  • brain excitatory neurons: 18 nCPM
  • oligodendrocyte progenitor cells: 18 nCPM
  • astrocytes: 16 nCPM

Immune cell

  • non-classical monocyte: 23 nTPM
  • intermediate monocyte: 18 nTPM
  • classical monocyte: 12 nTPM
  • total PBMC: 12 nTPM
  • neutrophil: 11 nTPM
  • NK-cell: 9.8 nTPM

Brain region

  • cerebral cortex: 72 nTPM
  • medulla oblongata: 69 nTPM
  • hippocampal formation: 68 nTPM
  • cerebellum: 65 nTPM
  • thalamus: 65 nTPM
  • basal ganglia: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
2.6
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATG9A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATG9A as an antibody target. Whether an autoantibody or antibody against ATG9A could matter depends on whether native ATG9A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATG9A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATG9A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATG9A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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