Seroatlas · Human Serome Atlas

MRPL13

Large ribosomal subunit protein uL13m

Also known as: L13, L13A, L13mt, RM13_HUMAN, RPL13, RPML13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BYD1
Gene
MRPL13
Ensembl
ENSG00000172172
Chromosome
8
Canonical length
178 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>Q9BYD1|MRPL13
     1  MSSFSRAPQQ WATFARIWYL LDGKMQPPGK LAAMASIRLQ GLHKPVYHAL SDCGDHVVIM
    61  NTRHIAFSGN KWEQKVYSSH TGYPGGFRQV TAAQLHLRDP VAIVKLAIYG MLPKNLHRRT
   121  MMERLHLFPD EYIPEDILKN LVEELPQPRK IPKRLDEYTQ EEIDAFPRLW TPPEDYRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • liver: 48 nTPM
  • tongue: 44 nTPM
  • kidney: 40 nTPM
  • colon: 35 nTPM
  • rectum: 34 nTPM
  • heart muscle: 34 nTPM

Single-cell type

  • esophageal suprabasal cells: 248 nCPM
  • parietal cells: 225 nCPM
  • esophageal basal cells: 209 nCPM
  • extravillous trophoblasts: 208 nCPM
  • gastric progenitor cells: 186 nCPM
  • migrating cytotrophoblasts: 180 nCPM

Immune cell

  • non-classical monocyte: 104 nTPM
  • intermediate monocyte: 92 nTPM
  • total PBMC: 92 nTPM
  • myeloid DC: 90 nTPM
  • T-reg: 78 nTPM
  • plasmacytoid DC: 73 nTPM

Brain region

  • white matter: 16 nTPM
  • hypothalamus: 16 nTPM
  • spinal cord: 15 nTPM
  • choroid plexus: 15 nTPM
  • cerebellum: 14 nTPM
  • thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.52
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL13 as an antibody target. Whether an autoantibody or antibody against MRPL13 could matter depends on whether native MRPL13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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