Seroatlas · Human Serome Atlas

MRPL27

Large ribosomal subunit protein bL27m

Also known as: RM27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0M9
Gene: MRPL27
Ensembl: ENSG00000108826
Chromosome: 17
Canonical length: 148 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>Q9P0M9|MRPL27
     1  MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR QGIKKMEGHY
    61  VHAGNIIATQ RHFRWHPGAH VGVGKNKCLY ALEEGIVRYT KEVYVPHPRN TEAVDLITRL
   121  PKGAVLYKTF VHVVPAKPEG TFKLVAML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 144 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 144 nTPM
tongue: 131 nTPM
choroid plexus: 120 nTPM
liver: 111 nTPM
epididymis: 109 nTPM
heart muscle: 107 nTPM

Single-cell type

syncytiotrophoblasts: 316 nCPM
parietal cells: 311 nCPM
cytotrophoblasts: 280 nCPM
migrating cytotrophoblasts: 273 nCPM
esophageal suprabasal cells: 272 nCPM
esophageal basal cells: 263 nCPM

Immune cell

basophil: 213 nTPM
memory B-cell: 212 nTPM
intermediate monocyte: 210 nTPM
plasmacytoid DC: 194 nTPM
naive B-cell: 188 nTPM
total PBMC: 180 nTPM

Brain region

thalamus: 53 nTPM
cerebellum: 52 nTPM
white matter: 50 nTPM
medulla oblongata: 49 nTPM
pons: 47 nTPM
spinal cord: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.5
gnomAD missense Z: -0.54
DepMap mean gene effect: -0.5
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Large ribosomal subunit protein bL27
Ribosomal L27 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL27 as an antibody target. Whether an autoantibody or antibody against MRPL27 could matter depends on whether native MRPL27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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