Seroatlas · Human Serome Atlas

NGRN

Neugrin

Also known as: DSC92, NGRN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPE2
Gene: NGRN
Ensembl: ENSG00000182768
Chromosome: 15
Canonical length: 291 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytokinetic bridge,Mitochondria
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables rRNA binding activity. Involved in mitochondrial ribosome assembly and positive regulation of mitochondrial translation. Located in several cellular components, including mitochondrion; mitotic spindle; and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q9NPE2|NGRN
     1  MAVTLSLLLG GRVCAAVTRC GFATRGVAGP GPIGREPDPD SDWEPEEREL QEVESTLKRQ
    61  KQAIRFQKIR RQMEAPGAPP RTLTWEAMEQ IRYLHEEFPE SWSVPRLAEG FDVSTDVIRR
   121  VLKSKFLPTL EQKLKQDQKV LKKAGLAHSL QHLRGSGNTS KLLPAGHSVS GSLLMPGHEA
   181  SSKDPNHSTA LKVIESDTHR TNTPRRRKGR NKEIQDLEES FVPVAAPLGH PRELQKYSSD
   241  SESPRGTGSG ALPSGQKLEE LKAEEPDNFS SKVVQRGREF FDSNGNFLYR I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NGRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 403 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 403 nTPM
skeletal muscle: 363 nTPM
amygdala: 312 nTPM
basal ganglia: 288 nTPM
hypothalamus: 275 nTPM
tongue: 272 nTPM

Single-cell type

other brain neurons: 8.1 nCPM
brain excitatory neurons: 5.1 nCPM
oocytes: 4.6 nCPM
brain inhibitory neurons: 4.5 nCPM
endometrial secretory cells: 2.9 nCPM
medullary thymic epithelial cells: 2.4 nCPM

Immune cell

T-reg: 134 nTPM
naive CD4 T-cell: 123 nTPM
MAIT T-cell: 110 nTPM
memory B-cell: 108 nTPM
total PBMC: 108 nTPM
naive CD8 T-cell: 107 nTPM

Brain region

cerebral cortex: 148 nTPM
thalamus: 146 nTPM
basal ganglia: 136 nTPM
hypothalamus: 132 nTPM
spinal cord: 124 nTPM
midbrain: 118 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Neugrin/Rrg9
Neugrin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NGRN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NGRN as an antibody target. Whether an autoantibody or antibody against NGRN could matter depends on whether native NGRN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NGRN is annotated as secreted, so native NGRN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NGRN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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