Seroatlas · Human Serome Atlas

MRPL58

Large ribosomal subunit protein mL62

Also known as: DS-1, ICT1, ICT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14197
Gene
MRPL58
Ensembl
ENSG00000167862
Chromosome
17
Canonical length
206 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoplasm,Plasma membrane,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q14197|MRPL58
     1  MAATRCLRWG LSRAGVWLLP PPARCPRRAL HKQKDGTEFK SIYSLDKLYP ESQGSDTAWR
    61  VPNGAKQADS DIPLDRLTIS YCRSSGPGGQ NVNKVNSKAE VRFHLATAEW IAEPVRQKIA
   121  ITHKNKINRL GELILTSESS RYQFRNLADC LQKIRDMITE ASQTPKEPTK EDVKLHRIRI
   181  ENMNRERLRQ KRIHSAVKTS RRVDMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 76 nTPM
  • tongue: 47 nTPM
  • heart muscle: 46 nTPM
  • liver: 44 nTPM
  • choroid plexus: 36 nTPM
  • adrenal gland: 34 nTPM

Single-cell type

  • esophageal suprabasal cells: 97 nCPM
  • esophageal basal cells: 93 nCPM
  • cytotrophoblasts: 77 nCPM
  • migrating cytotrophoblasts: 72 nCPM
  • oocytes: 60 nCPM
  • gastric progenitor cells: 59 nCPM

Immune cell

  • T-reg: 67 nTPM
  • myeloid DC: 55 nTPM
  • total PBMC: 43 nTPM
  • NK-cell: 42 nTPM
  • classical monocyte: 41 nTPM
  • intermediate monocyte: 41 nTPM

Brain region

  • choroid plexus: 36 nTPM
  • white matter: 21 nTPM
  • cerebellum: 20 nTPM
  • hypothalamus: 19 nTPM
  • pons: 18 nTPM
  • spinal cord: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.42
gnomAD pLI
0
DepMap mean gene effect
-0.43
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL58 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL58 as an antibody target. Whether an autoantibody or antibody against MRPL58 could matter depends on whether native MRPL58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL58. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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