Seroatlas · Human Serome Atlas

MRPL10

Large ribosomal subunit protein uL10m

Also known as: L10MT, MGC17973, MRP-L10, MRP-L8, MRPL8, RM10_HUMAN, RPML8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7H8
Gene
MRPL10
Ensembl
ENSG00000159111
Chromosome
17
Canonical length
261 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q7Z7H8|MRPL10
     1  MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV TEYIPPKPAI
    61  HPSCLPSPPS PPQEEIGLIR LLRREIAAVF QDNRMIAVCQ NVALSAEDKL LMRHQLRKHK
   121  ILMKVFPNQV LKPFLEDSKY QNLLPLFVGH NMLLVSEEPK VKEMVRILRT VPFLPLLGGC
   181  IDDTILSRQG FINYSKLPSL PLVQGELVGG LTCLTAQTHS LLQHQPLQLT TLLDQYIREQ
   241  REKDSVMSAN GKPDPDTVPD S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 62 nTPM
  • heart muscle: 55 nTPM
  • tongue: 49 nTPM
  • ovary: 48 nTPM
  • urinary bladder: 40 nTPM
  • blood vessel: 39 nTPM

Single-cell type

  • cytotrophoblasts: 107 nCPM
  • migrating cytotrophoblasts: 99 nCPM
  • syncytiotrophoblasts: 85 nCPM
  • extravillous trophoblasts: 69 nCPM
  • esophageal apical cells: 68 nCPM
  • decidual stromal cells: 66 nCPM

Immune cell

  • gdT-cell: 62 nTPM
  • MAIT T-cell: 59 nTPM
  • memory CD8 T-cell: 55 nTPM
  • T-reg: 53 nTPM
  • myeloid DC: 43 nTPM
  • memory CD4 T-cell: 42 nTPM

Brain region

  • thalamus: 23 nTPM
  • cerebellum: 21 nTPM
  • hypothalamus: 21 nTPM
  • white matter: 21 nTPM
  • medulla oblongata: 21 nTPM
  • basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0.1
gnomAD missense Z
0.08
DepMap mean gene effect
-0.75
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL10 as an antibody target. Whether an autoantibody or antibody against MRPL10 could matter depends on whether native MRPL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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