Seroatlas · Human Serome Atlas

MRPL41

Large ribosomal subunit protein mL41

Also known as: BMRP, MRP-L27, MRPL27, PIG3, RM41_HUMAN, RPML27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IXM3
Gene
MRPL41
Ensembl
ENSG00000182154
Chromosome
9
Canonical length
137 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>Q8IXM3|MRPL41
     1  MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF VQIKEMVPEF
    61  VVPDLTGFKL KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI EKDFKDGTFD PDNLEKYGFE
   121  PTQEGKLFQL YPRNFLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
826 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 826 nTPM
  • skeletal muscle: 488 nTPM
  • cerebral cortex: 438 nTPM
  • amygdala: 426 nTPM
  • basal ganglia: 415 nTPM
  • liver: 397 nTPM

Single-cell type

  • late spermatids: 1,160 nCPM
  • parietal cells: 1,029 nCPM
  • hepatocytes: 999 nCPM
  • colonocytes: 592 nCPM
  • enterocytes: 400 nCPM
  • late primary spermatocytes: 340 nCPM

Immune cell

  • basophil: 427 nTPM
  • plasmacytoid DC: 424 nTPM
  • total PBMC: 351 nTPM
  • T-reg: 333 nTPM
  • memory B-cell: 315 nTPM
  • classical monocyte: 307 nTPM

Brain region

  • thalamus: 257 nTPM
  • amygdala: 239 nTPM
  • cerebral cortex: 238 nTPM
  • medulla oblongata: 214 nTPM
  • hippocampal formation: 212 nTPM
  • basal ganglia: 206 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0.56
gnomAD missense Z
0.42
DepMap mean gene effect
-0.68
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein mL41
  • Mitochondrial ribosomal protein L27

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL41 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL41 as an antibody target. Whether an autoantibody or antibody against MRPL41 could matter depends on whether native MRPL41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL41. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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