Seroatlas · Human Serome Atlas

MRPL1

Large ribosomal subunit protein uL1m

Also known as: BM022, RM01_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYD6
Gene: MRPL1
Ensembl: ENSG00000169288
Chromosome: 4
Canonical length: 325 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q9BYD6|MRPL1
     1  MAAAVRCMGR ALIHHQRHSL SKMVYQTSLC SCSVNIRVPN RHFAAATKSA KKTKKGAKEK
    61  TPDEKKDEIE KIKAYPYMEG EPEDDVYLKR LYPRQIYEVE KAVHLLKKFQ ILDFTSPKQS
   121  VYLDLTLDMA LGKKKNVEPF TSVLSLPYPF ASEINKVAVF TENASEVKIA EENGAAFAGG
   181  TSLIQKIWDD EIVADFYVAV PEIMPELNRL RKKLNKKYPK LSRNSIGRDI PKMLELFKNG
   241  HEIKVDEERE NFLQTKIATL DMSSDQIAAN LQAVINEVCR HRPLNLGPFV VRAFLRSSTS
   301  EGLLLKIDPL LPKEVKNEES EKEDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

tongue: 63 nTPM
skeletal muscle: 63 nTPM
heart muscle: 39 nTPM
kidney: 36 nTPM
liver: 32 nTPM
rectum: 28 nTPM

Single-cell type

t-cells: 230 nCPM
nk-cells: 183 nCPM
erythrocyte progenitors: 169 nCPM
hepatocytes: 153 nCPM
epididymal clear cells: 129 nCPM
gonadotrophs: 127 nCPM

Immune cell

naive CD8 T-cell: 30 nTPM
memory B-cell: 28 nTPM
naive CD4 T-cell: 27 nTPM
T-reg: 26 nTPM
naive B-cell: 26 nTPM
NK-cell: 23 nTPM

Brain region

cerebral cortex: 20 nTPM
hypothalamus: 18 nTPM
pons: 17 nTPM
basal ganglia: 17 nTPM
white matter: 17 nTPM
spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Large ribosomal subunit protein uL1, 3-layer alpha/beta-sandwich domain
Ribosomal protein uL1-like
Ribosomal protein uL1/ribosomal biogenesis protein
Ribosomal protein L1p/L10e family
Large ribosomal subunit protein uL1, mitochondrial

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL1 as an antibody target. Whether an autoantibody or antibody against MRPL1 could matter depends on whether native MRPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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