Seroatlas · Human Serome Atlas

MRPL17

Large ribosomal subunit protein bL17m

Also known as: MRP-L26, RM17_HUMAN, RPML26

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRX2
Gene: MRPL17
Ensembl: ENSG00000158042
Chromosome: 11
Canonical length: 175 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>Q9NRX2|MRPL17
     1  MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD EMRGYAEKLI
    61  DYGKLGDTNE RAMRMADFWL TEKDLIPKLF QVLAPRYKDQ TGGYTRMLQI PNRSLDRAKM
   121  AVIEYKGNCL PPLPLPRRDS HLTLLNQLLQ GLRQDLRQSQ EASNHSSHTA QTPGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 28 nTPM
heart muscle: 27 nTPM
esophagus: 27 nTPM
kidney: 24 nTPM
pituitary gland: 23 nTPM
skeletal muscle: 22 nTPM

Single-cell type

extravillous trophoblasts: 174 nCPM
esophageal basal cells: 157 nCPM
megakaryocytes: 148 nCPM
esophageal suprabasal cells: 138 nCPM
late primary spermatocytes: 136 nCPM
migrating cytotrophoblasts: 123 nCPM

Immune cell

plasmacytoid DC: 64 nTPM
T-reg: 43 nTPM
memory CD4 T-cell: 42 nTPM
naive CD4 T-cell: 41 nTPM
memory B-cell: 39 nTPM
intermediate monocyte: 37 nTPM

Brain region

hypothalamus: 12 nTPM
thalamus: 12 nTPM
cerebral cortex: 11 nTPM
medulla oblongata: 11 nTPM
basal ganglia: 11 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0.03
gnomAD missense Z: -0.28
DepMap mean gene effect: -0.53
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Large ribosomal subunit protein bL17
Large ribosomal subunit protein bL17 superfamily
Ribosomal protein L17

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL17 as an antibody target. Whether an autoantibody or antibody against MRPL17 could matter depends on whether native MRPL17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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