Seroatlas · Human Serome Atlas

TRUB2

Pseudouridylate synthase TRUB2, mitochondrial

Also known as: CLONE24922, TRUB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95900
Gene: TRUB2
Ensembl: ENSG00000167112
Chromosome: 9
Canonical length: 331 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>O95900|TRUB2
     1  MGSAGLSRLH GLFAVYKPPG LKWKHLRDTV ELQLLKGLNA RKPPAPKQRV RFLLGPMEGS
    61  EEKELTLTAT SVPSFINHPL VCGPAFAHLK VGVGHRLDAQ ASGVLVLGVG HGCRLLTDMY
   121  NAHLTKDYTV RGLLGKATDD FREDGRLVEK TTYDHVTREK LDRILAVIQG SHQKALVMYS
   181  NLDLKTQEAY EMAVRGLIRP MNKSPMLITG IRCLYFAPPE FLLEVQCMHE TQKELRKLVH
   241  EIGLELKTTA VCTQVRRTRD GFFTLDSALL RTQWDLTNIQ DAIRAATPQV AAELEKSLSP
   301  GLDTKQLPSP GWSWDSQGPS STLGLERGAG Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRUB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

liver: 13 nTPM
midbrain: 9.5 nTPM
choroid plexus: 9.4 nTPM
cerebral cortex: 9.1 nTPM
tongue: 9.1 nTPM
amygdala: 9 nTPM

Single-cell type

esophageal basal cells: 77 nCPM
esophageal suprabasal cells: 75 nCPM
cytotrophoblasts: 63 nCPM
hepatocytes: 62 nCPM
extravillous trophoblasts: 54 nCPM
migrating cytotrophoblasts: 53 nCPM

Immune cell

NK-cell: 6.4 nTPM
memory B-cell: 6.3 nTPM
T-reg: 6.2 nTPM
MAIT T-cell: 5.7 nTPM
memory CD8 T-cell: 5.7 nTPM
naive CD8 T-cell: 5.7 nTPM

Brain region

pons: 20 nTPM
white matter: 19 nTPM
midbrain: 19 nTPM
thalamus: 19 nTPM
medulla oblongata: 19 nTPM
cerebral cortex: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Pseudouridine synthase II, N-terminal
Pseudouridine synthase, catalytic domain superfamily
TruB family pseudouridylate synthase (N terminal domain)
Mitochondrial pseudouridylate synthase Trub2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRUB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRUB2 as an antibody target. Whether an autoantibody or antibody against TRUB2 could matter depends on whether native TRUB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRUB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRUB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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