Seroatlas · Human Serome Atlas

MRPL52

Large ribosomal subunit protein mL52

Also known as: RM52_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86TS9
Gene
MRPL52
Ensembl
ENSG00000172590
Chromosome
14
Canonical length
123 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q86TS9|MRPL52
     1  MAALGTVLFT GVRRLHCSVA AWAGGQWRLQ QGLAANPSGY GPLTELPDWS YADGRPAPPM
    61  KGQLRRKAER ETFARRVVLL SQEMDAGLQA WQLRQQKLQE EQRKQENALK PKGASLKSPL
   121  PSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
184 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 184 nTPM
  • skeletal muscle: 149 nTPM
  • liver: 146 nTPM
  • kidney: 144 nTPM
  • esophagus: 135 nTPM
  • midbrain: 123 nTPM

Single-cell type

  • gastric progenitor cells: 588 nCPM
  • esophageal suprabasal cells: 406 nCPM
  • extravillous trophoblasts: 345 nCPM
  • esophageal basal cells: 328 nCPM
  • hepatocytes: 319 nCPM
  • parietal cells: 304 nCPM

Immune cell

  • myeloid DC: 160 nTPM
  • memory B-cell: 141 nTPM
  • plasmacytoid DC: 132 nTPM
  • intermediate monocyte: 129 nTPM
  • naive B-cell: 112 nTPM
  • classical monocyte: 112 nTPM

Brain region

  • medulla oblongata: 52 nTPM
  • cerebellum: 52 nTPM
  • pons: 51 nTPM
  • white matter: 50 nTPM
  • thalamus: 48 nTPM
  • spinal cord: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein mL52
  • Mitoribosomal protein mL52

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL52 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL52 as an antibody target. Whether an autoantibody or antibody against MRPL52 could matter depends on whether native MRPL52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL52. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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