Seroatlas · Human Serome Atlas

CCDC85B

Coiled-coil domain-containing protein 85B

Also known as: CC85B_HUMAN, DIPA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15834
Gene: CCDC85B
Ensembl: ENSG00000175602
Chromosome: 11
Canonical length: 202 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q15834|CCDC85B
     1  MEAEAGGLEE LTDEEMAALG KEELVRRLRR EEAARLAALV QRGRLMQEVN RQLQGHLGEI
    61  RELKQLNRRL QAENRELRDL CCFLDSERQR GRRAARQWQL FGTQASRAVR EDLGGCWQKL
   121  AELEGRQEEL LRENLALKEL CLALGEEWGP RGGPSGAGGS GAGPAPELAL PPCGPRDLGD
   181  GSSSTGSVGS PDQLPLACSP DD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC85B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 367 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 367 nTPM
amygdala: 326 nTPM
cerebral cortex: 310 nTPM
basal ganglia: 227 nTPM
midbrain: 189 nTPM
heart muscle: 138 nTPM

Single-cell type

platelets: 542 nCPM
decidual stromal cells: 417 nCPM
megakaryocytes: 359 nCPM
vascular endothelial cells: 333 nCPM
hepatic stellate cells: 239 nCPM
basal keratinocytes: 215 nCPM

Immune cell

naive CD4 T-cell: 25 nTPM
memory B-cell: 23 nTPM
memory CD8 T-cell: 22 nTPM
MAIT T-cell: 22 nTPM
eosinophil: 21 nTPM
naive CD8 T-cell: 20 nTPM

Brain region

hippocampal formation: 234 nTPM
cerebral cortex: 226 nTPM
amygdala: 195 nTPM
thalamus: 192 nTPM
medulla oblongata: 163 nTPM
basal ganglia: 150 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0.31
gnomAD missense Z: 1.57
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

delta-catenin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC85B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC85B as an antibody target. Whether an autoantibody or antibody against CCDC85B could matter depends on whether native CCDC85B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC85B is annotated at the cell surface, where native CCDC85B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCDC85B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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