Seroatlas · Human Serome Atlas

ZCCHC10

Zinc finger CCHC domain-containing protein 10

Also known as: FLJ20094, ZCH10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBK6
Gene: ZCCHC10
Ensembl: ENSG00000155329
Chromosome: 5
Canonical length: 192 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli rim

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q8TBK6|ZCCHC10
     1  MATPMHRLIA RRQAFDTELQ PVKTFWILIQ PSIVISEANK QHVRCQKCLE FGHWTYECTG
    61  KRKYLHRPSR TAELKKALKE KENRLLLQQS IGETNVERKA KKKRSKSVTS SSSSSSDSSA
   121  SDSSSESEET STSSSSEDSD TDESSSSSSS SASSTTSSSS SDSDSDSSSS SSSSTSTDSS
   181  SDDEPPKKKK KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCCHC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 36 nTPM
lymph node: 27 nTPM
tonsil: 27 nTPM
colon: 24 nTPM
skeletal muscle: 23 nTPM
thymus: 22 nTPM

Single-cell type

esophageal apical cells: 227 nCPM
b-cells: 124 nCPM
colonocytes: 104 nCPM
extravillous trophoblasts: 98 nCPM
undifferentiated spermatogonia: 98 nCPM
goblet cells: 97 nCPM

Immune cell

naive B-cell: 123 nTPM
memory B-cell: 103 nTPM
T-reg: 71 nTPM
non-classical monocyte: 67 nTPM
myeloid DC: 67 nTPM
classical monocyte: 66 nTPM

Brain region

cerebellum: 25 nTPM
cerebral cortex: 24 nTPM
choroid plexus: 23 nTPM
hypothalamus: 23 nTPM
midbrain: 22 nTPM
thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.06
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCHC-type superfamily
Zinc knuckle
Zinc finger CCHC domain-containing protein 10

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZCCHC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCCHC10 as an antibody target. Whether an autoantibody or antibody against ZCCHC10 could matter depends on whether native ZCCHC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCCHC10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCCHC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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