Seroatlas · Human Serome Atlas

RIPPLY3

Protein ripply3

Also known as: DSCR6, DSCR6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57055
Gene: RIPPLY3
Ensembl: ENSG00000183145
Chromosome: 21
Canonical length: 190 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in embryonic pattern specification and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>P57055|RIPPLY3
     1  MEPEAAAGAR KARGRGCHCP GDAPWRPPPP RGPESPAPWR PWIQTPGDAE LTRTGRPLEP
    61  RADQHTFGSK GAFGFQHPVR VYLPMSKRQE YLRSSGEQVL ASFPVQATID FYDDESTESA
   121  SEAEEPEEGP PPLHLLPQEV GGRQENGPGG KGRDQGINQG QRSSGGGDHW GEGPLPQGVS
   181  SRGGKCSSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIPPLY3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

kidney: 0.2 nTPM
parathyroid gland: 0.2 nTPM
basal ganglia: 0.1 nTPM
cervix: 0.1 nTPM
esophagus: 0.1 nTPM
lung: 0.1 nTPM

Single-cell type

alveolar cells type 1: 6.2 nCPM
epididymal principal cells: 5.1 nCPM
retinal pigment epithelial cells: 4.3 nCPM
pancreatic islet cells: 3.9 nCPM
extravillous trophoblasts: 3.3 nCPM
transitional alveolar cells: 3.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 1.7 nTPM
cerebral cortex: 0.5 nTPM
cerebellum: 0.2 nTPM
thalamus: 0.2 nTPM
amygdala: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0.08
gnomAD missense Z: -0.29
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIPPLY3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIPPLY3 as an antibody target. Whether an autoantibody or antibody against RIPPLY3 could matter depends on whether native RIPPLY3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIPPLY3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIPPLY3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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