INSYN1
Inhibitory synaptic factor 1
Also known as: C15orf59, INSY1_HUMAN, LOC388135, MGC131524
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q2T9L4
- Gene
- INSYN1
- Ensembl
- ENSG00000205363
- Chromosome
- 15
- Canonical length
- 293 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to be involved in inhibitory postsynaptic potential. Predicted to be located in synapse. Predicted to be active in GABA-ergic synapse and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
293 residues, UniProt reviewed canonical sequence.
>Q2T9L4|INSYN1
1 MNIRGAPDLG QPSDDPSSGG ERERIRQRMK MVIGQLEGIL RELKEVAKEL REVVSQIDKL
61 TSDFDFELEP DDWTTATVSS TSSSDKAGMG GPFDLGHLDF MTADILSDSW EFCSFLDVST
121 PSDSVDGPES TRPGAGPDYR LMNGGTPIPN GPRVETPDSS SEEAFGAGPT VKSQLPQRTP
181 GTRERVRFSD KVLYHALCCD DEEGDGEQEV EEEEVGLPPE PAHTEAHAGP HKPSPAPYKS
241 RRSPLTSRHS GSTLAPEQTR RVTRNSSTQT VSDKSTQTVL PYTATRQKAR GKNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against INSYN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 45 nTPM
Expression across tissuesHPA
Tissue
- midbrain: 45 nTPM
- heart muscle: 42 nTPM
- cerebral cortex: 40 nTPM
- basal ganglia: 32 nTPM
- hippocampal formation: 32 nTPM
- amygdala: 30 nTPM
Single-cell type
- bergmann glia: 32 nCPM
- podocytes: 19 nCPM
- astrocytes: 18 nCPM
- brain inhibitory neurons: 14 nCPM
- renal collecting duct intercalated cells: 12 nCPM
- retinal amacrine cells: 12 nCPM
Immune cell
- basophil: 0.1 nTPM
- neutrophil: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- midbrain: 123 nTPM
- thalamus: 101 nTPM
- cerebral cortex: 90 nTPM
- hippocampal formation: 83 nTPM
- white matter: 72 nTPM
- amygdala: 70 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.84
- gnomAD pLI
- 0.11
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of INSYN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads INSYN1 as an antibody target. Whether an autoantibody or antibody against INSYN1 could matter depends on whether native INSYN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
INSYN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label INSYN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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