Seroatlas · Human Serome Atlas

ZNF365

Protein ZNF365

Also known as: KIAA0844, Su48, UAN, ZN365_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q70YC5
Gene
ZNF365
Ensembl
ENSG00000138311
Chromosome
10
Canonical length
407 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Centriolar satellite,Centrosome
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast cancer susceptibility. [provided by RefSeq, Mar 2020]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q70YC5|ZNF365
     1  MQQKAFEESR YPWQESFENV AVCLPLRCPR CGDHTRFRSL SSLRAHLEFS HSYEERTLLT
    61  KCSLFPSLKD TDLVTSSELL KPGKLQSSGN VVKQKPSYVN LYSISHEHSK DRKPFEVVAE
   121  RPVSYVQTYT AMDLHADSLD GTRSGPGLPT SDTKASFEAH VREKFNRMVE AVDRTIEKRI
   181  DKLTKELAQK TAELLEVRAA FVQLTQKKQE VQRRERALNR QVDVAVEMIA VLRQRLTESE
   241  EELLRKEEEV VTFNHFLEAA AEKEVQGKAR LQDFIENLLQ RVELAEKQLE YYQSQQASGF
   301  VRDLSGHVLT DISSNRKPKC LSRGHPHSVC NHPDLKAHFH PKGRNHLKKA KDDRASMQPA
   361  KAIHEQAESS RDLCRPPKKG ELLGFGRKGN IRPKMAKKKP TAIVNII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF365 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 34 nTPM
  • spinal cord: 11 nTPM
  • esophagus: 9.6 nTPM
  • hippocampal formation: 8.7 nTPM
  • cerebellum: 8.2 nTPM
  • basal ganglia: 8 nTPM

Single-cell type

  • proximal tubule cells: 34 nCPM
  • papillary tip epithelial cells: 20 nCPM
  • renal connecting tubule cells: 13 nCPM
  • podocytes: 5.7 nCPM
  • renal collecting duct principal cells: 3.5 nCPM
  • distal convoluted tubule cells: 3 nCPM

Immune cell

  • NK-cell: 6.4 nTPM
  • T-reg: 5.9 nTPM
  • memory CD8 T-cell: 2.7 nTPM
  • naive CD8 T-cell: 2.7 nTPM
  • gdT-cell: 2.4 nTPM
  • memory CD4 T-cell: 2.2 nTPM

Brain region

  • cerebral cortex: 103 nTPM
  • white matter: 89 nTPM
  • thalamus: 60 nTPM
  • basal ganglia: 49 nTPM
  • midbrain: 45 nTPM
  • hippocampal formation: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF365 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF365 as an antibody target. Whether an autoantibody or antibody against ZNF365 could matter depends on whether native ZNF365 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF365 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF365 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF365. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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