Seroatlas · Human Serome Atlas

ZNF581

Zinc finger protein 581

Also known as: FLJ22550, HSPC189, ZN581_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0T4
Gene: ZNF581
Ensembl: ENSG00000171425
Chromosome: 19
Canonical length: 197 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q9P0T4|ZNF581
     1  MLVLPSPCPQ PLAFSSVETM EGPPRRTCRS PEPGPSSSIG SPQASSPPRP NHYLLIDTQG
    61  VPYTVLVDEE SQREPGASGA PGQKKCYSCP VCSRVFEYMS YLQRHSITHS EVKPFECDIC
   121  GKAFKRASHL ARHHSIHLAG GGRPHGCPLC PRRFRDAGEL AQHSRVHSGE RPFQCPHCPR
   181  RFMEQNTLQK HTRWKHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF581 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

ovary: 36 nTPM
pancreas: 34 nTPM
spleen: 28 nTPM
skin: 27 nTPM
esophagus: 24 nTPM
cervix: 23 nTPM

Single-cell type

hematopoietic stem cells: 0.5 nCPM
epididymal efferent duct absorptive cells: 0.3 nCPM
endometrial stromal cells: 0.2 nCPM
enterocytes: 0.2 nCPM
epididymal basal cells: 0.2 nCPM
fallopian secretory cells: 0.2 nCPM

Immune cell

naive B-cell: 84 nTPM
memory B-cell: 81 nTPM
intermediate monocyte: 51 nTPM
classical monocyte: 42 nTPM
myeloid DC: 42 nTPM
T-reg: 41 nTPM

Brain region

medulla oblongata: 12 nTPM
cerebellum: 11 nTPM
thalamus: 11 nTPM
choroid plexus: 11 nTPM
spinal cord: 11 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0.09
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF581 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF581 as an antibody target. Whether an autoantibody or antibody against ZNF581 could matter depends on whether native ZNF581 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF581 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF581 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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